|
|
| (12 intermediate revisions by the same user not shown) |
| Line 1: |
Line 1: |
| [[Image:1ojb.gif|left|200px]]<br /> | | #REDIRECT [[2xfu]] This PDB entry is obsolete and replaced by 2xfu |
| <applet load="1ojb" size="450" color="white" frame="true" align="right" spinBox="true"
| |
| caption="1ojb, resolution 2.20Å" />
| |
| '''HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH TRANYLCYPROMINE'''<br />
| |
| | |
| ==Overview==
| |
| Monoamine oxidase B (MAO-B) is an outer mitochondrial membrane-bound, enzyme that catalyzes the oxidative deamination of arylalkylamine, neurotransmitters and has been a target for a number of clinically used, drug inhibitors. The 1.7-A structure of the reversible isatin-MAO-B, complex has been determined; it forms a basis for the interpretation of, the enzyme's structure when bound to either reversible or irreversible, inhibitors. 1,4-Diphenyl-2-butene is found to be a reversible MAO-B, inhibitor, which occupies both the entrance and substrate cavity space in, the enzyme. Comparison of these two structures identifies Ile-199 as a, "gate" between the two cavities. Rotation of the side chain allows for, either separation or fusion of the two cavities. Inhibition of the enzyme, with ... [[http://ispc.weizmann.ac.il/pmbin/getpm?12913124 (full description)]]
| |
| | |
| ==About this Structure==
| |
| 1OJB is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FAD and 1LP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Amine_oxidase_(flavin-containing) Amine oxidase (flavin-containing)]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.4 1.4.3.4]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OJB OCA]].
| |
| | |
| ==Reference==
| |
| Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures., Binda C, Li M, Hubalek F, Restelli N, Edmondson DE, Mattevi A, Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9750-5. Epub 2003 Aug 11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12913124 12913124]
| |
| [[Category: Amine oxidase (flavin-containing)]]
| |
| [[Category: Homo sapiens]]
| |
| [[Category: Single protein]]
| |
| [[Category: Binda, C.]]
| |
| [[Category: Edmondson, D.E.]]
| |
| [[Category: Mattevi, A.]]
| |
| [[Category: 1LP]]
| |
| [[Category: FAD]]
| |
| [[Category: fad-containing amine oxidase]]
| |
| [[Category: maob]]
| |
| [[Category: oxidoreductase]]
| |
| | |
| ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:25:42 2007''
| |
This PDB entry is obsolete and replaced by 2xfu
