2le6: Difference between revisions

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[[Image:2le6.jpg|left|200px]]


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==Structure of a dimeric all-parallel-stranded G-quadruplex stacked via the 5'-to-5' interface==
The line below this paragraph, containing "STRUCTURE_2le6", creates the "Structure Box" on the page.
<StructureSection load='2le6' size='340' side='right'caption='[[2le6]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2le6]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LE6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2le6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2le6 OCA], [https://pdbe.org/2le6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2le6 RCSB], [https://www.ebi.ac.uk/pdbsum/2le6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2le6 ProSAT]</span></td></tr>
{{STRUCTURE_2le6|  PDB=2le6  |  SCENE=  }}
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== Publication Abstract from PubMed ==
G-rich oligonucleotides T30695 (or T30923), with the sequence of (GGGT)(4), and T40214, with the sequence of (GGGC)(4), have been reported to exhibit anti-HIV and anticancer activity. Here we report on the structure of a dimeric G-quadruplex adopted by a derivative of these sequences in K(+) solution. It comprises two identical propeller-type parallel-stranded G-quadruplex subunits each containing three G-tetrad layers that are stacked via the 5'-5' interface. We demonstrated control over the stacking of the two monomeric subunits by sequence modifications. Our analysis of possible structures at the stacking interface provides a general principle for stacking of G-quadruplexes, which could have implications for the assembly and recognition of higher-order G-quadruplex structures.


===Structure of a dimeric all-parallel-stranded G-quadruplex stacked via the 5'-to-5' interface===
Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity.,Do NQ, Lim KW, Teo MH, Heddi B, Phan AT Nucleic Acids Res. 2011 Aug 12. PMID:21840903<ref>PMID:21840903</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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(as it appears on PubMed at http://www.pubmed.gov), where 21840903 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21840903}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[2le6]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LE6 OCA].
[[Category: Do NQ]]
 
[[Category: Heddi B]]
==Reference==
[[Category: Lim KW]]
<ref group="xtra">PMID:021840903</ref><references group="xtra"/>
[[Category: Phan AT]]
[[Category: Do, N Q.]]
[[Category: Teo MH]]
[[Category: Heddi, B.]]
[[Category: Lim, K W.]]
[[Category: Phan, A T.]]
[[Category: Teo, M H.]]
[[Category: Anticancer]]
[[Category: Dna]]
[[Category: G-quadruplex]]
[[Category: Hiv-1 integrase inhibition]]
[[Category: Stacking]]
Retrieved from "https://proteopedia.org/2le6"