TonB: Difference between revisions

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{{STRUCTURE_1xx3 |  PDB=1xx3  |  SCENE= TonB/Ctdtonb/1 }}
<StructureSection load='1ihr' size='350' side='right' scene='' caption='E. coli TonB C-terminal dimer complex with Br- ions (dark red) (PDB code [[1ihr]])'>
{{STRUCTURE_1xx3|  PDB=1xx3  | SIZE=400| SCENE=TonB/Ctdtonb/1 |right|CAPTION=E. coli TonB, [[1xx3]] }}


==Structure==
==Structure==
The structure to the right (1XX3) shows the structure of TonB.  The protein spans the periplasm <ref>PMID: 16741125</ref>, with the C-terminus of TonB spanning from residues ~150 to 239<ref name='Postle'>PMID: 21179522</ref>.
'''TonB''' spans the periplasm <ref>PMID: 16741125</ref>, with the C-terminus of TonB spanning from residues ~150 to 239<ref name='Postle'>PMID: 21179522</ref>.  For more details on the Ton system see [[Ton]].


==Function==
==Function==
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===BtuB-TonB Complex===
===BtuB-TonB Complex===
{{STRUCTURE_2gsk |  PDB=2gsk |  SCENE= BtuB-TonB_Complex/Btubtonbcomplex/1 }}
 
<StructureSection load='2gsk' size='350' side='right' scene='BtuB-TonB_Complex/Btubtonbcomplex/1' caption='E. coli TonB C-terminal (green) complex with vitamin B12 transporter BtuB (grey) (PDB code [[2gsk]])'>
As shown in the 3D structure to the right (2GSK), TonB complexes with [[BtuB]] in order to aid the transport of nutrients such as cobalamins<ref name='Cadieux'>PMID 11029413</ref> across the outer membrane by incorporating the proton-motive force into the outer membrane.<ref name='Shultis'>PMID: 16741124</ref>  TonB attaches to BtuB on the periplasmic side of the 614 amino acid BtuB protein<ref name='Shultis'> PMID: 16741124</ref>.
As shown in the 3D structure to the right (2GSK), TonB complexes with [[BtuB]] in order to aid the transport of nutrients such as cobalamins<ref name='Cadieux'>PMID 11029413</ref> across the outer membrane by incorporating the proton-motive force into the outer membrane.<ref name='Shultis'>PMID: 16741124</ref>  TonB attaches to BtuB on the periplasmic side of the 614 amino acid BtuB protein<ref name='Shultis'> PMID: 16741124</ref>.
</StructureSection>
==3D structures of TonB==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[1ihr]], [[1qxx]], [[1u07]] – EcTonB C terminal – ''Escherichia coli''<br />
[[1xx3]], [[5lw8]] - EcTonB C terminal – NMR<br />
[[2grx]] - EcTonB + ferrichrome-iron receptor<br />
[[2ivz]] - EcTonB + colicin-E9 peptide<br />
[[2gsk]] - EcTonB C terminal + vitamin B12 transporter BtuB<br />
[[2k9k]] – TonB2 C terminal – ''Listonella anguillarum''<br />
[[6fip]] - PaTonB C terminal – ''Pseudomonas aeruginosa'' - NMR<br />
[[6i97]] - PaTonB C terminal + TonB-dependent receptor <br />
[[5lw8]], [[6sly]] - TonB C terminal – ''Helicobacter pylori'' - NMR<br />


== References==
== References==
<references/>
<references/>
[[Category:Topic Page]]
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