2w1z: Difference between revisions

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[[Image:2w1z.png|left|200px]]


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==ROP2 from Toxoplasma gondii: A virulence factor with a protein- kinase fold and no enzymatic activity.==
The line below this paragraph, containing "STRUCTURE_2w1z", creates the "Structure Box" on the page.
<StructureSection load='2w1z' size='340' side='right'caption='[[2w1z]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2w1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii_RH Toxoplasma gondii RH]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W1Z FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_2w1z|  PDB=2w1z  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w1z OCA], [https://pdbe.org/2w1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w1z RCSB], [https://www.ebi.ac.uk/pdbsum/2w1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w1z ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q27007_TOXGO Q27007_TOXGO]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The ROP2 protein and its paralogs are important virulence factors secreted into the host cell by the parasite Toxoplasma gondii. Here we describe the crystal structure of a large and soluble domain of mature ROP2, representative of the ROP2-like protein family. This is a structure of a protein-kinase fold that is devoid of catalytic residues and does not bind ATP. Various structural extensions constitute a signature of this protein family and act to maintain the protein kinase in an open conformation. Our ROP2 structure rules out a previous structural model of attachment of ROP2-like proteins to the parasitophorous vacuole membrane. We propose an alternative mode of membrane attachment implicating basic and amphiphatic helices present in the flexible N terminus of ROP2.


===ROP2 FROM TOXOPLASMA GONDII: A VIRULENCE FACTOR WITH A PROTEIN-KINASE FOLD AND NO ENZYMATIC ACTIVITY.===
ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity.,Labesse G, Gelin M, Bessin Y, Lebrun M, Papoin J, Cerdan R, Arold ST, Dubremetz JF Structure. 2009 Jan 14;17(1):139-46. PMID:19141290<ref>PMID:19141290</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_19141290}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2w1z" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19141290 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_19141290}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[2w1z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W1Z OCA].
[[Category: Toxoplasma gondii RH]]
 
[[Category: Arold ST]]
==Reference==
[[Category: Bessin Y]]
<ref group="xtra">PMID:019141290</ref><references group="xtra"/>
[[Category: Dubremetz J-F]]
[[Category: Toxoplasma gondii]]
[[Category: Gelin M]]
[[Category: Arold, S T.]]
[[Category: Labesse G]]
[[Category: Bessin, Y.]]
[[Category: Lebrun M]]
[[Category: Dubremetz, J F.]]
[[Category: Gelin, M.]]
[[Category: Labesse, G.]]
[[Category: Lebrun, M.]]
[[Category: Inactivity]]
[[Category: Membrane-attachment]]
[[Category: Protein-kinase]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2w1z"