3tq8: Difference between revisions
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New page: '''Unreleased structure''' The entry 3tq8 is ON HOLD Authors: Franklin, M.C., Cassidy, M., Hillerich, B., Love, J. Description: Structure of the dihydrofolate reductase (folA) from Cox... |
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==Structure of the dihydrofolate reductase (folA) from Coxiella burnetii in complex with trimethoprim== | |||
<StructureSection load='3tq8' size='340' side='right'caption='[[3tq8]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3tq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxiella_burnetii Coxiella burnetii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TQ8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TOP:TRIMETHOPRIM'>TOP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tq8 OCA], [https://pdbe.org/3tq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tq8 RCSB], [https://www.ebi.ac.uk/pdbsum/3tq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tq8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q83AB2_COXBU Q83AB2_COXBU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194] | |||
==See Also== | |||
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Coxiella burnetii]] | |||
[[Category: Large Structures]] | |||
[[Category: Cassidy M]] | |||
[[Category: Franklin MC]] | |||
[[Category: Hillerich B]] | |||
[[Category: Love J]] | |||
