3zvr: Difference between revisions

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[[Image:3zvr.png|left|200px]]


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==Crystal structure of Dynamin==
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<StructureSection load='3zvr' size='340' side='right'caption='[[3zvr]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3zvr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZVR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr>
{{STRUCTURE_3zvr|  PDB=3zvr  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zvr OCA], [https://pdbe.org/3zvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zvr RCSB], [https://www.ebi.ac.uk/pdbsum/3zvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zvr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYN1_RAT DYN1_RAT] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Dynamin-related proteins (DRPs) are multi-domain GTPases that function via oligomerization and GTP-dependent conformational changes to play central roles in regulating membrane structure across phylogenetic kingdoms. How DRPs harness self-assembly and GTP-dependent conformational changes to remodel membranes is not understood. Here we present the crystal structure of an assembly-deficient mammalian endocytic DRP, dynamin 1, lacking the proline-rich domain, in its nucleotide-free state. The dynamin 1 monomer is an extended structure with the GTPase domain and bundle signalling element positioned on top of a long helical stalk with the pleckstrin homology domain flexibly attached on its opposing end. Dynamin 1 dimer and higher order dimer multimers form via interfaces located in the stalk. Analysis of these interfaces provides insight into DRP family member specificity and regulation and provides a framework for understanding the biogenesis of higher order DRP structures and the mechanism of DRP-mediated membrane scission events.


===CRYSTAL STRUCTURE OF DYNAMIN===
The crystal structure of dynamin.,Ford MG, Jenni S, Nunnari J Nature. 2011 Sep 18. doi: 10.1038/nature10441. PMID:21927001<ref>PMID:21927001</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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(as it appears on PubMed at http://www.pubmed.gov), where 21927001 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21927001}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3zvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZVR OCA].
 
==Reference==
<ref group="xtra">PMID:021927001</ref><references group="xtra"/>
[[Category: Dynamin GTPase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Ford, M G.J.]]
[[Category: Ford MGJ]]
[[Category: Jenni, S.]]
[[Category: Jenni S]]
[[Category: Nunnari, J.]]
[[Category: Nunnari J]]
[[Category: Bse]]
[[Category: Drp]]
[[Category: Drp1]]
[[Category: Endocytosis]]
[[Category: Gtpase]]
[[Category: Hydrolase]]
[[Category: Membrane fission]]
[[Category: Mitochondrial fission]]
[[Category: Ph]]
[[Category: Stalk]]
Retrieved from "https://proteopedia.org/3zvr"