3tu8: Difference between revisions
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New page: '''Unreleased structure''' The entry 3tu8 is ON HOLD Authors: Cruz, A., Hautbergue, G.M., Artymiuk, P.J., Baker, P.J., Chang, Ch.T., Mahadi, N.M., Mobbs, G.W., Mohamed, R., Nathan, Sh.,... |
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==Crystal Structure of the Burkholderia Lethal Factor 1 (BLF1)== | |||
<StructureSection load='3tu8' size='340' side='right'caption='[[3tu8]], [[Resolution|resolution]] 1.04Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3tu8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TU8 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.04Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tu8 OCA], [https://pdbe.org/3tu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tu8 RCSB], [https://www.ebi.ac.uk/pdbsum/3tu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tu8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q63UP7_BURPS Q63UP7_BURPS] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia lethal factor 1. | |||
A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.,Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, Marshall LE, Mobbs GW, Mohamed R, Nathan S, Ngugi SA, Ong C, Ooi WF, Partridge LJ, Phillips HL, Raih MF, Ruzheinikov S, Sarkar-Tyson M, Sedelnikova SE, Smither SJ, Tan P, Titball RW, Wilson SA, Rice DW Science. 2011 Nov 11;334(6057):821-4. PMID:22076380<ref>PMID:22076380</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3tu8" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Burkholderia pseudomallei]] | |||
[[Category: Large Structures]] | |||
[[Category: Artymiuk PJ]] | |||
[[Category: Baker PJ]] | |||
[[Category: Chang CT]] | |||
[[Category: Cruz A]] | |||
[[Category: Hautbergue GM]] | |||
[[Category: Mahadi NM]] | |||
[[Category: Mobbs GW]] | |||
[[Category: Mohamed R]] | |||
[[Category: Nathan S]] | |||
[[Category: Partridge LJ]] | |||
[[Category: Raih MF]] | |||
[[Category: Rice DW]] | |||
[[Category: Ruzheinikov SN]] | |||
[[Category: Sedelnikova SE]] | |||
[[Category: Wilson SA]] | |||
Latest revision as of 06:12, 17 October 2024
Crystal Structure of the Burkholderia Lethal Factor 1 (BLF1)
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