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[[Image:1h30.gif|left|200px]]<br />
<applet load="1h30" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1h30, resolution 2.2&Aring;" />
'''C-TERMINAL LG DOMAIN PAIR OF HUMAN GAS6'''<br />


==Overview==
==C-terminal LG domain pair of human Gas6==
Receptor tyrosine kinases of the Axl family are activated by Gas6, the, product of growth arrest-specific gene 6. Gas6-Axl signaling is implicated, in cell survival, adhesion, and migration. The receptor-binding site of, Gas6 is located within a C-terminal pair of laminin G-like (LG) domains, that do not resemble any other receptor tyrosine kinase ligand. We report, the crystal structure at 2.2-A resolution of a Gas6 fragment spanning both, LG domains (Gas6-LG). The structure reveals a V-shaped arrangement of LG, domains strengthened by an interdomain calcium-binding site. LG2 of, Gas6-LG contains two unusual features: an alpha-helix cradled by one edge, of the LG beta-sandwich and a conspicuous patch of surface-exposed, hydrophobic residues. Mutagenesis of some residues in this patch ... [[http://ispc.weizmann.ac.il/pmbin/getpm?12218057 (full description)]]
<StructureSection load='1h30' size='340' side='right'caption='[[1h30]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1h30]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H30 FirstGlance]. <br>
1H30 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: CAA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H30 OCA]].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h30 OCA], [https://pdbe.org/1h30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h30 RCSB], [https://www.ebi.ac.uk/pdbsum/1h30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h30 ProSAT]</span></td></tr>
Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains., Sasaki T, Knyazev PG, Cheburkin Y, Gohring W, Tisi D, Ullrich A, Timpl R, Hohenester E, J Biol Chem. 2002 Nov 15;277(46):44164-70. Epub 2002 Sep 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12218057 12218057]
</table>
== Function ==
[https://www.uniprot.org/uniprot/GAS6_HUMAN GAS6_HUMAN] Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.<ref>PMID:12364394</ref> <ref>PMID:18840707</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/1h30_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h30 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Cheburkin, Y.]]
[[Category: Cheburkin Y]]
[[Category: Gohring, W.]]
[[Category: Gohring W]]
[[Category: Hohenester, E.]]
[[Category: Hohenester E]]
[[Category: Knyazev, P.G.]]
[[Category: Knyazev PG]]
[[Category: Sasaki, T.]]
[[Category: Sasaki T]]
[[Category: Timpl, R.]]
[[Category: Timpl R]]
[[Category: Tisi, D.]]
[[Category: Tisi D]]
[[Category: Ullrich, A.]]
[[Category: Ullrich A]]
[[Category: CA]]
[[Category: SO4]]
[[Category: axl/sky/mer ligand]]
[[Category: calcium-binding]]
[[Category: egf-like domain]]
[[Category: laminin g-like domain]]
[[Category: vitamin k-dependent protein]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:30:16 2007''

Latest revision as of 11:27, 27 March 2024

C-terminal LG domain pair of human Gas6

1h30, resolution 2.20Å

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