3t8v: Difference between revisions

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[[Image:3t8v.jpg|left|200px]]


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==A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases==
The line below this paragraph, containing "STRUCTURE_3t8v", creates the "Structure Box" on the page.
<StructureSection load='3t8v' size='340' side='right'caption='[[3t8v]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3t8v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_FcB1/Columbia Plasmodium falciparum FcB1/Columbia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T8V FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTJ:N-[(2-{2-[(N-{(2S,3R)-3-AMINO-4-[4-(BENZYLOXY)PHENYL]-2-HYDROXYBUTANOYL}-L-ALANYL)AMINO]ETHOXY}ETHOXY)ACETYL]-4-BENZOYL-L-PHENYLALANYL-N~6~-HEX-5-YNOYLLYSINAMIDE'>BTJ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3t8v|  PDB=3t8v  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t8v OCA], [https://pdbe.org/3t8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t8v RCSB], [https://www.ebi.ac.uk/pdbsum/3t8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t8v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AMP1_PLAFQ AMP1_PLAFQ] Displays aminopeptidase activity with a broad substrate specificity. Preferentially hydrolyzes L-Lys-AMC but also shows strong activity against L-Ala-AMC, L-Arg-AMC and L-Leu-AMC.<ref>PMID:12166515</ref> <ref>PMID:19196988</ref>


===A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases===
==See Also==
 
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_21844374}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 21844374 is the PubMed ID number.
</StructureSection>
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_21844374}}
[[Category: Plasmodium falciparum FcB1/Columbia]]
 
[[Category: Greebaum DC]]
==About this Structure==
[[Category: Klemba M]]
[[3t8v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T8V OCA].
[[Category: McGowan S]]
 
==Reference==
<ref group="xtra">PMID:021844374</ref><references group="xtra"/>
[[Category: Plasmodium falciparum]]
[[Category: Greebaum, D C.]]
[[Category: Klemba, M.]]
[[Category: McGowan, S.]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: M1 alanyl-aminopeptidase]]
[[Category: Metallo-aminopeptidase]]
[[Category: Protease]]
Retrieved from "https://proteopedia.org/3t8v"