3t5k: Difference between revisions

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'''Unreleased structure'''


The entry 3t5k is ON HOLD  until Paper Publication
==Ternary complex of HNE Adduct modified DNA (5'-TXG-3' vs 14-mer) with Dpo4 and incoming dDTP==
<StructureSection load='3t5k' size='340' side='right'caption='[[3t5k]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3t5k]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T5K FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene>, <scene name='pdbligand=HN0:2-DEOXY-N-[(2S,3S,5R)-5-HYDROXY-2-PENTYLTETRAHYDROFURAN-3-YL]GUANOSINE+5-(DIHYDROGEN+PHOSPHATE)'>HN0</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t5k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5k OCA], [https://pdbe.org/3t5k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t5k RCSB], [https://www.ebi.ac.uk/pdbsum/3t5k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5k ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPO4_SACS2 DPO4_SACS2] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.


Authors: Banerjee, S., Christov, P.P., Kozekova, A., Rizzo, C.J., Stone, M.P.
==See Also==
 
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
Description: Ternary complex of HNE Adduct modified DNA (5'-TXG-3' vs 14-mer) with Dpo4 and incoming dDTP
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharolobus solfataricus P2]]
[[Category: Banerjee S]]
[[Category: Christov PP]]
[[Category: Kozekova A]]
[[Category: Rizzo CJ]]
[[Category: Stone MP]]
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