3u0r: Difference between revisions

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'''Unreleased structure'''


The entry 3u0r is ON HOLD
==Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules==
 
<StructureSection load='3u0r' size='340' side='right'caption='[[3u0r]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
Authors: Han, B.G., KIm, K.H., Jeong, K.C., Cho, J.W., Noh, K.H., Kim, T.W., Yoon, H.J., Suh, S.W., Lee, S.H., Lee, B.I.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3u0r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U0R FirstGlance]. <br>
Description: Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0r OCA], [https://pdbe.org/3u0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u0r RCSB], [https://www.ebi.ac.uk/pdbsum/3u0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u0r ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cho JW]]
[[Category: Han BG]]
[[Category: Jeong KC]]
[[Category: Kim KH]]
[[Category: Kim TW]]
[[Category: Lee BI]]
[[Category: Lee SH]]
[[Category: Noh KH]]
[[Category: Suh SW]]
[[Category: Yoon HJ]]
Retrieved from "https://proteopedia.org/3u0r"