3t42: Difference between revisions

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[[Image:3t42.jpg|left|200px]]


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==Human aldose reductase in complex with a nitrile-containing IDD inhibitor==
The line below this paragraph, containing "STRUCTURE_3t42", creates the "Structure Box" on the page.
<StructureSection load='3t42' size='340' side='right'caption='[[3t42]], [[Resolution|resolution]] 1.28&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3t42]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T42 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.28&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3T4:{5-CHLORO-2-[(4-CYANO-3-NITROBENZYL)CARBAMOYL]PHENOXY}ACETIC+ACID'>3T4</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
{{STRUCTURE_3t42|  PDB=3t42  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t42 OCA], [https://pdbe.org/3t42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t42 RCSB], [https://www.ebi.ac.uk/pdbsum/3t42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t42 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


===Human aldose reductase in complex with a nitrile-containing IDD inhibitor===
==See Also==
 
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_21859105}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 21859105 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_21859105}}
 
==About this Structure==
[[3t42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T42 OCA].
 
==Reference==
<ref group="xtra">PMID:021859105</ref><references group="xtra"/>
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Boxer, S G.]]
[[Category: Large Structures]]
[[Category: Cohen, A E.]]
[[Category: Boxer SG]]
[[Category: Xu, L.]]
[[Category: Cohen AE]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Xu L]]
[[Category: Tim barrel]]

Latest revision as of 13:16, 14 March 2024

Human aldose reductase in complex with a nitrile-containing IDD inhibitor

3t42, resolution 1.28Å

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