3q2u: Difference between revisions

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[[Image:3q2u.jpg|left|200px]]


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==Structure of Human Glioma Pathogenesis-related Protein 1 Reveals Unique loops and surface motifs.==
The line below this paragraph, containing "STRUCTURE_3q2u", creates the "Structure Box" on the page.
<StructureSection load='3q2u' size='340' side='right'caption='[[3q2u]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3q2u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q2U FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_3q2u|  PDB=3q2u  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q2u OCA], [https://pdbe.org/3q2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q2u RCSB], [https://www.ebi.ac.uk/pdbsum/3q2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q2u ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLIP1_HUMAN GLIP1_HUMAN]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Human glioma pathogenesis-related protein 1 (GLIPR1) is a membrane protein that is highly upregulated in brain cancers but is barely detectable in normal brain tissue. GLIPR1 is composed of a signal peptide that directs its secretion, a conserved cysteine-rich CAP (cysteine-rich secretory proteins, antigen 5 and pathogenesis-related 1 proteins) domain and a transmembrane domain. GLIPR1 is currently being investigated as a candidate for prostate cancer gene therapy and for glioblastoma targeted therapy. Crystal structures of a truncated soluble domain of the human GLIPR1 protein (sGLIPR1) solved by molecular replacement using a truncated polyalanine search model of the CAP domain of stecrisp, a snake-venom cysteine-rich secretory protein (CRISP), are presented. The correct molecular-replacement solution could only be obtained by removing all loops from the search model. The native structure was refined to 1.85 A resolution and that of a Zn(2+) complex was refined to 2.2 A resolution. The latter structure revealed that the putative binding cavity coordinates Zn(2+) similarly to snake-venom CRISPs, which are involved in Zn(2+)-dependent mechanisms of inflammatory modulation. Both sGLIPR1 structures have extensive flexible loop/turn regions and unique charge distributions that were not observed in any of the previously reported CAP protein structures. A model is also proposed for the structure of full-length membrane-bound GLIPR1.


===Structure of Human Glioma Pathogenesis-related Protein 1 Reveals Unique loops and surface motifs.===
Structural studies of human glioma pathogenesis-related protein 1.,Asojo OA, Koski RA, Bonafe N Acta Crystallogr D Biol Crystallogr. 2011 Oct;67(Pt 10):847-55. Epub 2011, Sep 8. PMID:21931216<ref>PMID:21931216</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3q2u" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 21931216 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21931216}}
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</StructureSection>
==About this Structure==
[[3q2u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q2U OCA].
 
==Reference==
<ref group="xtra">PMID:021931216</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Asojo, O A.]]
[[Category: Large Structures]]
[[Category: Crisp]]
[[Category: Asojo OA]]
[[Category: Membrane protein]]
[[Category: Rtvp1]]
Retrieved from "https://proteopedia.org/3q2u"