3rzu: Difference between revisions

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[[Image:3rzu.png|left|200px]]


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==The Crystal Structure of the Catalytic Domain of AMSH==
The line below this paragraph, containing "STRUCTURE_3rzu", creates the "Structure Box" on the page.
<StructureSection load='3rzu' size='340' side='right'caption='[[3rzu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3rzu]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RZU FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3rzu|  PDB=3rzu  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rzu OCA], [https://pdbe.org/3rzu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rzu RCSB], [https://www.ebi.ac.uk/pdbsum/3rzu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rzu ProSAT]</span></td></tr>
 
</table>
===The Crystal Structure of the Catalytic Domain of AMSH===
== Disease ==
 
[https://www.uniprot.org/uniprot/STABP_HUMAN STABP_HUMAN] Microcephaly-capillary malformation syndrome. The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
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[https://www.uniprot.org/uniprot/STABP_HUMAN STABP_HUMAN] Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (By similarity). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways.<ref>PMID:10383417</ref> <ref>PMID:11483516</ref> <ref>PMID:15314065</ref> <ref>PMID:17261583</ref> <ref>PMID:23542699</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_21888914}}, adds the Publication Abstract to the page
== References ==
(as it appears on PubMed at http://www.pubmed.gov), where 21888914 is the PubMed ID number.
<references/>
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__TOC__
{{ABSTRACT_PUBMED_21888914}}
</StructureSection>
 
==About this Structure==
[[3rzu]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZU OCA].  
 
==Reference==
<ref group="xtra">PMID:021888914</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Das, C.]]
[[Category: Large Structures]]
[[Category: Davies, C W.]]
[[Category: Das C]]
[[Category: Endosome-associated deubiquitinating enzyme]]
[[Category: Davies CW]]
[[Category: Hydrolase]]
[[Category: Stam]]
[[Category: Ubiquitin hydrolase]]
Retrieved from "https://proteopedia.org/3rzu"