3zyn: Difference between revisions

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[[Image:3zyn.png|left|200px]]


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==Crystal structure of the N-terminal leucine rich repeats of Netrin-G Ligand-3==
The line below this paragraph, containing "STRUCTURE_3zyn", creates the "Structure Box" on the page.
<StructureSection load='3zyn' size='340' side='right'caption='[[3zyn]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3zyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZYN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
{{STRUCTURE_3zyn|  PDB=3zyn  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zyn OCA], [https://pdbe.org/3zyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zyn RCSB], [https://www.ebi.ac.uk/pdbsum/3zyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zyn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LRC4B_MOUSE LRC4B_MOUSE] Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Brain wiring depends on cells making highly localized and selective connections through surface protein-protein interactions, including those between NetrinGs and NetrinG ligands (NGLs). The NetrinGs are members of the structurally uncharacterized netrin family. We present a comprehensive crystallographic analysis comprising NetrinG1-NGL1 and NetrinG2-NGL2 complexes, unliganded NetrinG2 and NGL3. Cognate NetrinG-NGL interactions depend on three specificity-conferring NetrinG loops, clasped tightly by matching NGL surfaces. We engineered these NGL surfaces to implant custom-made affinities for NetrinG1 and NetrinG2. In a cellular patterning assay, we demonstrate that NetrinG-binding selectivity can direct the sorting of a mixed population of NGLs into discrete cell surface subdomains. These results provide a molecular model for selectivity-based patterning in a neuronal recognition system, dysregulation of which is associated with severe neuropsychological disorders.


===CRYSTAL STRUCTURE OF THE N-TERMINAL LEUCINE RICH REPEATS OF NETRIN-G LIGAND-3===
Structural basis for cell surface patterning through NetrinG-NGL interactions.,Seiradake E, Coles CH, Perestenko PV, Harlos K, McIlhinney RA, Aricescu AR, Jones EY EMBO J. 2011 Sep 23. doi: 10.1038/emboj.2011.346. PMID:21946559<ref>PMID:21946559</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3zyn" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 21946559 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21946559}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3zyn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYN OCA].
 
==Reference==
<ref group="xtra">PMID:021946559</ref><references group="xtra"/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Aricescu, A R.]]
[[Category: Aricescu AR]]
[[Category: Coles, C H.]]
[[Category: Coles CH]]
[[Category: Harlos, K.]]
[[Category: Harlos K]]
[[Category: Jones, E Y.]]
[[Category: Jones EY]]
[[Category: Mcilhinney, R A.J.]]
[[Category: McIlhinney RAJ]]
[[Category: Perestenko, P V.]]
[[Category: Perestenko PV]]
[[Category: Seiradake, E.]]
[[Category: Seiradake E]]
[[Category: Cell adhesion]]
[[Category: Synapse]]

Latest revision as of 11:16, 20 December 2023

Crystal structure of the N-terminal leucine rich repeats of Netrin-G Ligand-3

3zyn, resolution 3.20Å

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