3tu8: Difference between revisions

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'''Unreleased structure'''


The entry 3tu8 is ON HOLD
==Crystal Structure of the Burkholderia Lethal Factor 1 (BLF1)==
<StructureSection load='3tu8' size='340' side='right'caption='[[3tu8]], [[Resolution|resolution]] 1.04&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3tu8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TU8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.04&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tu8 OCA], [https://pdbe.org/3tu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tu8 RCSB], [https://www.ebi.ac.uk/pdbsum/3tu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tu8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q63UP7_BURPS Q63UP7_BURPS]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia lethal factor 1.


Authors: Cruz, A., Hautbergue, G.M., Artymiuk, P.J., Baker, P.J., Chang, C.T., Mahadi, N.M., Mobbs, G.W., Mohamed, R., Nathan, S., Partridge, L.J., Raih, M.F., Ruzheinikov, S.N., Sedelnikova, S.E., Wilson, S.A., Rice, D.W.
A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A.,Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, Marshall LE, Mobbs GW, Mohamed R, Nathan S, Ngugi SA, Ong C, Ooi WF, Partridge LJ, Phillips HL, Raih MF, Ruzheinikov S, Sarkar-Tyson M, Sedelnikova SE, Smither SJ, Tan P, Titball RW, Wilson SA, Rice DW Science. 2011 Nov 11;334(6057):821-4. PMID:22076380<ref>PMID:22076380</ref>


Description: Crystal Structure of the Burkholderia Lethal Factor 1 (BLF1)
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3tu8" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Burkholderia pseudomallei]]
[[Category: Large Structures]]
[[Category: Artymiuk PJ]]
[[Category: Baker PJ]]
[[Category: Chang CT]]
[[Category: Cruz A]]
[[Category: Hautbergue GM]]
[[Category: Mahadi NM]]
[[Category: Mobbs GW]]
[[Category: Mohamed R]]
[[Category: Nathan S]]
[[Category: Partridge LJ]]
[[Category: Raih MF]]
[[Category: Rice DW]]
[[Category: Ruzheinikov SN]]
[[Category: Sedelnikova SE]]
[[Category: Wilson SA]]
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