3u50: Difference between revisions
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New page: '''Unreleased structure''' The entry 3u50 is ON HOLD Authors: Zeng, Z., Huang, J., Yang, Y., Lei, M. Description: Crystal Structure of the Tetrahymena telomerase processivity factor Te... |
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==Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 OB-C== | |||
<StructureSection load='3u50' size='340' side='right'caption='[[3u50]], [[Resolution|resolution]] 2.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3u50]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U50 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u50 OCA], [https://pdbe.org/3u50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u50 RCSB], [https://www.ebi.ac.uk/pdbsum/3u50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u50 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TEB1_TETTS TEB1_TETTS] Single-stranded DNA (ssDNA)-binding protein that mediates the recruitment of telomerase to telomeric DNA (PubMed:19941821, PubMed:20363756, PubMed:25225329, PubMed:22143754). Telomerase is an essential ribonucleoprotein (RNP) enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:19941821). Acts as part of a replication protein A (RPA)-related subcomplex of the holoenzyme telomerase ribonucleoprotein complex: TEB1 specifically recognizes and binds telomeric ssDNA, thereby mediating the recruitment of the holoenzyme telomerase RNP complex to telomeres (PubMed:19941821, PubMed:25225329, PubMed:27895115). TEB1 is related to RPA1 subunit of the RPA complex but is specific to telomeric DNA, which is not the case of RPA1 (PubMed:25225329).<ref>PMID:19941821</ref> <ref>PMID:20363756</ref> <ref>PMID:22143754</ref> <ref>PMID:25225329</ref> <ref>PMID:27895115</ref> | |||
==See Also== | |||
*[[Telomerase-associated protein|Telomerase-associated protein]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Tetrahymena thermophila]] | |||
[[Category: Huang J]] | |||
[[Category: Lei M]] | |||
[[Category: Yang Y]] | |||
[[Category: Zeng Z]] | |||
Latest revision as of 10:17, 1 March 2024
Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 OB-C
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