3u9m: Difference between revisions

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'''Unreleased structure'''


The entry 3u9m is ON HOLD
==Structure of reduced human FBXL5 hemerythrin like domain==
 
<StructureSection load='3u9m' size='340' side='right'caption='[[3u9m]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
Authors: Li, P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3u9m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U9M FirstGlance]. <br>
Description: Structure of reduced human FBXL5 hemerythrin like domain
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u9m OCA], [https://pdbe.org/3u9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u9m RCSB], [https://www.ebi.ac.uk/pdbsum/3u9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u9m ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FBXL5_HUMAN FBXL5_HUMAN] Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.<ref>PMID:17532294</ref> <ref>PMID:19762596</ref> <ref>PMID:19762597</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Li P]]
Retrieved from "https://proteopedia.org/3u9m"