3t7t: Difference between revisions

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[[Image:3t7t.png|left|200px]]


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==Crystal structure of complex of SAH and BVU_3255, a methyltransferase from Bacteroides vulgatus ATCC 8482==
The line below this paragraph, containing "STRUCTURE_3t7t", creates the "Structure Box" on the page.
<StructureSection load='3t7t' size='340' side='right'caption='[[3t7t]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3t7t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Phocaeicola_vulgatus_ATCC_8482 Phocaeicola vulgatus ATCC 8482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T7T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
{{STRUCTURE_3t7t|  PDB=3t7t  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7t OCA], [https://pdbe.org/3t7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t7t RCSB], [https://www.ebi.ac.uk/pdbsum/3t7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t7t ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A6L5C0_PHOV8 A6L5C0_PHOV8]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Methylation is important for various cellular activities. To date, there is no report of any methyltransferase structure from the human intestine antibiotic resistant pathogen Bacteroides vulgatus. The protein BVU_3255 from B. vulgatus ATCC 8482 belongs to a SAM-dependent methyltransferase. Here, we report the crystal structure of apo BVU_3255, and its complexes with SAM and SAH, which revealed a typical class I Rossmann Fold Methyltransferase. Isothermal titration calorimetric studies showed that both SAM and SAH bind with equal affinity. The structural and sequence analysis suggested that BVU_3255 is a small molecule methyltransferase and involved in methylating the intermediates in ubiquinone biosynthesis pathway.


===Crystal structure of complex of SAH and BVU_3255, a methyltransferase from Bacteroides vulgatus ATCC 8482===
Structural characterization of BVU_3255, a methyltransferase from human intestine antibiotic resistant pathogen Bacteroides vulgatus.,Kumar V, Sivaraman J J Struct Biol. 2011 Aug 22. PMID:21872662<ref>PMID:21872662</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_21872662}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3t7t" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 21872662 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21872662}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3t7t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteroides_vulgatus Bacteroides vulgatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7T OCA].
[[Category: Phocaeicola vulgatus ATCC 8482]]
 
[[Category: Kumar V]]
==Reference==
[[Category: Sivaraman J]]
<ref group="xtra">PMID:021872662</ref><references group="xtra"/>
[[Category: Bacteroides vulgatus]]
[[Category: Kumar, V.]]
[[Category: Sivaraman, J.]]
[[Category: Bvu_3255]]
[[Category: Methylation]]
[[Category: Methyltrasnferase]]
[[Category: Rossmann fold]]
[[Category: Sam]]
[[Category: Small molecule methyltransferase]]
[[Category: Transferase]]

Latest revision as of 17:29, 1 November 2023

Crystal structure of complex of SAH and BVU_3255, a methyltransferase from Bacteroides vulgatus ATCC 8482

3t7t, resolution 2.50Å

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