3zyc: Difference between revisions

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[[Image:3zyc.png|left|200px]]


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==DYNAMIN 1 GTPASE GED FUSION DIMER COMPLEXED WITH GMPPCP==
The line below this paragraph, containing "STRUCTURE_3zyc", creates the "Structure Box" on the page.
<StructureSection load='3zyc' size='340' side='right'caption='[[3zyc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3zyc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZYC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_3zyc|  PDB=3zyc  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zyc OCA], [https://pdbe.org/3zyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zyc RCSB], [https://www.ebi.ac.uk/pdbsum/3zyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zyc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The GTPase dynamin catalyzes membrane fission by forming a collar around the necks of clathrin-coated pits, but the specific structural interactions and conformational changes that drive this process remain a mystery. We present the GMPPCP-bound structures of the truncated human dynamin 1 helical polymer at 12.2 A and a fusion protein, GG, linking human dynamin 1's catalytic G domain to its GTPase effector domain (GED) at 2.2 A. The structures reveal the position and connectivity of dynamin fragments in the assembled structure, showing that G domain dimers only form between tetramers in sequential rungs of the dynamin helix. Using chemical crosslinking, we demonstrate that dynamin tetramers are made of two dimers, in which the G domain of one molecule interacts in trans with the GED of another. Structural comparison of GG(GMPPCP) to the GG transition-state complex identifies a hydrolysis-dependent powerstroke that may play a role in membrane-remodeling events necessary for fission.


===DYNAMIN 1 GTPASE GED FUSION DIMER COMPLEXED WITH GMPPCP===
A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke.,Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F Cell. 2011 Sep 30;147(1):209-22. PMID:21962517<ref>PMID:21962517</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_21962517}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3zyc" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 21962517 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21962517}}
__TOC__
 
</StructureSection>
==About this Structure==
[[3zyc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYC OCA].
 
==Reference==
<ref group="xtra">PMID:021962517</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chappie, J S.]]
[[Category: Large Structures]]
[[Category: Dyda, F.]]
[[Category: Chappie JS]]
[[Category: Fang, S.]]
[[Category: Dyda F]]
[[Category: Hinshaw, J E.]]
[[Category: Fang S]]
[[Category: Leonard, M.]]
[[Category: Hinshaw JE]]
[[Category: Mears, J A.]]
[[Category: Leonard M]]
[[Category: Milligan, R A.]]
[[Category: Mears JA]]
[[Category: Schmid, S L.]]
[[Category: Milligan RA]]
[[Category: Endocytosis]]
[[Category: Schmid SL]]
[[Category: Hydrolase]]
[[Category: Membrane fission]]
[[Category: Motor protein]]
[[Category: Nucleotide-binding]]
Retrieved from "https://proteopedia.org/3zyc"