3tnd: Difference between revisions

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[[Image:3tnd.jpg|left|200px]]


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==Crystal structure of Shigella flexneri VapBC toxin-antitoxin complex==
The line below this paragraph, containing "STRUCTURE_3tnd", creates the "Structure Box" on the page.
<StructureSection load='3tnd' size='340' side='right'caption='[[3tnd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3tnd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TND FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3tnd|  PDB=3tnd  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tnd OCA], [https://pdbe.org/3tnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tnd RCSB], [https://www.ebi.ac.uk/pdbsum/3tnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tnd ProSAT]</span></td></tr>
 
</table>
===Crystal structure of Shigella flexneri VapBC toxin-antitoxin complex===
== Function ==
 
[https://www.uniprot.org/uniprot/VAPC_SHIFL VAPC_SHIFL] Toxic component of a toxin-antitoxin (TA) module. A tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Does not cleave tRNA(Met), tRNA(Arg2), tRNA(His), tRNA(Leu), tRNA(Phe) tRNA(Thr1), tRNA(Tyr) or tRNA(Val). Overexpression in E.coli inhibits translation, leads to loss of cell growth and degradation of tRNA(fMet); these effects are neutralized by expression of cognate antitoxin VapB. The VapB/VapC complex probably regulates transcription of its own promoter.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref>  Ectopic overexpression in E.coli induces the YoeB toxin, but this is not the cause of VapC toxicity.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref>
 
== References ==
==About this Structure==
<references/>
[[3tnd]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TND OCA].  
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Shigella flexneri]]
[[Category: Shigella flexneri]]
[[Category: Boggild, A.]]
[[Category: Boggild A]]
[[Category: Brodersen, D E.]]
[[Category: Brodersen DE]]
[[Category: Dienemann, C.]]
[[Category: Dienemann C]]
[[Category: Gerdes, K.]]
[[Category: Gerdes K]]
[[Category: Winther, K S.]]
[[Category: Winther KS]]
[[Category: Dna-binding]]
[[Category: Pin domain]]
[[Category: Ribonuclease]]
[[Category: Spovt/abrb-like domain]]
[[Category: Toxin]]
[[Category: Translation]]
Retrieved from "https://proteopedia.org/3tnd"