4a6a: Difference between revisions
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==A115V variant of dCTP deaminase-dUTPase from Mycobacterium tuberculosis in complex with dTTP== | |||
<StructureSection load='4a6a' size='340' side='right'caption='[[4a6a]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4a6a]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A6A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a6a OCA], [https://pdbe.org/4a6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a6a RCSB], [https://www.ebi.ac.uk/pdbsum/4a6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a6a ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DCDB_MYCTU DCDB_MYCTU] Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. It also acts as a dUTP diphosphatase. Affinity for dCTP and dUTP are very similar.<ref>PMID:18164314</ref> | |||
==See Also== | |||
*[[DUTPase 3D structures|DUTPase 3D structures]] | |||
*[[Deaminase 3D structures|Deaminase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis H37Rv]] | |||
[[Category: Harris P]] | |||
[[Category: Lovgreen MN]] | |||
[[Category: Ucar E]] | |||
[[Category: Willemoes M]] | |||
Latest revision as of 10:47, 9 May 2024
A115V variant of dCTP deaminase-dUTPase from Mycobacterium tuberculosis in complex with dTTP
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