3zyi: Difference between revisions

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[[Image:3zyi.png|left|200px]]


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==NetrinG2 in complex with NGL2==
The line below this paragraph, containing "STRUCTURE_3zyi", creates the "Structure Box" on the page.
<StructureSection load='3zyi' size='340' side='right'caption='[[3zyi]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3zyi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZYI FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
{{STRUCTURE_3zyi|  PDB=3zyi  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zyi OCA], [https://pdbe.org/3zyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zyi RCSB], [https://www.ebi.ac.uk/pdbsum/3zyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zyi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LRRC4_HUMAN LRRC4_HUMAN] Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Brain wiring depends on cells making highly localized and selective connections through surface protein-protein interactions, including those between NetrinGs and NetrinG ligands (NGLs). The NetrinGs are members of the structurally uncharacterized netrin family. We present a comprehensive crystallographic analysis comprising NetrinG1-NGL1 and NetrinG2-NGL2 complexes, unliganded NetrinG2 and NGL3. Cognate NetrinG-NGL interactions depend on three specificity-conferring NetrinG loops, clasped tightly by matching NGL surfaces. We engineered these NGL surfaces to implant custom-made affinities for NetrinG1 and NetrinG2. In a cellular patterning assay, we demonstrate that NetrinG-binding selectivity can direct the sorting of a mixed population of NGLs into discrete cell surface subdomains. These results provide a molecular model for selectivity-based patterning in a neuronal recognition system, dysregulation of which is associated with severe neuropsychological disorders.


===NETRING2 IN COMPLEX WITH NGL2===
Structural basis for cell surface patterning through NetrinG-NGL interactions.,Seiradake E, Coles CH, Perestenko PV, Harlos K, McIlhinney RA, Aricescu AR, Jones EY EMBO J. 2011 Sep 23. doi: 10.1038/emboj.2011.346. PMID:21946559<ref>PMID:21946559</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3zyi" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_21946559}}, adds the Publication Abstract to the page
*[[Netrin|Netrin]]
(as it appears on PubMed at http://www.pubmed.gov), where 21946559 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21946559}}
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</StructureSection>
==About this Structure==
[[3zyi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZYI OCA].
 
==Reference==
<ref group="xtra">PMID:021946559</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Aricescu, A R.]]
[[Category: Large Structures]]
[[Category: Coles, C H.]]
[[Category: Aricescu AR]]
[[Category: Harlos, K.]]
[[Category: Coles CH]]
[[Category: Jones, E Y.]]
[[Category: Harlos K]]
[[Category: Mcilhinney, R A.J.]]
[[Category: Jones EY]]
[[Category: Perestenko, P V.]]
[[Category: McIlhinney RAJ]]
[[Category: Seiradake, E.]]
[[Category: Perestenko PV]]
[[Category: Cell adhesion]]
[[Category: Seiradake E]]
[[Category: Lrrc4 complex]]
[[Category: Synapse]]
Retrieved from "https://proteopedia.org/3zyi"