2llk: Difference between revisions
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New page: '''Unreleased structure''' The entry 2llk is ON HOLD Authors: Montecchio, M., Lemak, A., Yee, A., Xu, C., Garcia, M., Houliston, S., Min, J., Bellanda, M., Arrowsmith, C. Description: ... |
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==Solution NMR structure of the N-terminal myb-like 1 domain of the human cyclin-D-binding transcription factor 1 (hDMP1), Northeast Structural Genomics Consortium (NESG) target ID hr8011a== | |||
<StructureSection load='2llk' size='340' side='right'caption='[[2llk]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2llk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LLK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2llk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2llk OCA], [https://pdbe.org/2llk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2llk RCSB], [https://www.ebi.ac.uk/pdbsum/2llk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2llk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DMTF1_HUMAN DMTF1_HUMAN] Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.<ref>PMID:12917399</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith C]] | |||
[[Category: Bellanda M]] | |||
[[Category: Garcia M]] | |||
[[Category: Houliston S]] | |||
[[Category: Lemak A]] | |||
[[Category: Min J]] | |||
[[Category: Montecchio M]] | |||
[[Category: Montelione GT]] | |||
[[Category: Xu C]] | |||
[[Category: Yee A]] | |||
Latest revision as of 05:45, 15 May 2024
Solution NMR structure of the N-terminal myb-like 1 domain of the human cyclin-D-binding transcription factor 1 (hDMP1), Northeast Structural Genomics Consortium (NESG) target ID hr8011a
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