3qq5: Difference between revisions

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[[Image:3qq5.png|left|200px]]


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==Crystal structure of the [FeFe]-hydrogenase maturation protein HydF==
The line below this paragraph, containing "STRUCTURE_3qq5", creates the "Structure Box" on the page.
<StructureSection load='3qq5' size='340' side='right'caption='[[3qq5]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3qq5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_neapolitana_DSM_4359 Thermotoga neapolitana DSM 4359]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QQ5 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qq5 OCA], [https://pdbe.org/3qq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qq5 RCSB], [https://www.ebi.ac.uk/pdbsum/3qq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qq5 ProSAT]</span></td></tr>
{{STRUCTURE_3qq5|  PDB=3qq5  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/B9KBK7_THENN B9KBK7_THENN]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
[FeFe]-hydrogenases catalyze the reversible pro-duction of H2 in some bacteria and unicellular eu-karyotes. These enzymes require ancillary proteins to assemble the unique active site H-cluster, a com-plex structure composed of a 2Fe center bridged to a [4Fe-4S] cubane. The first crystal structure of a key factor in the maturation process, HydF, has been determined at 3A resolution. The protein monomer present in the asymmetric unit of the crystal comprises three domains: a GTP-binding domain, a dimerization domain and a metal-cluster binding domain, all characterized by similar fold-ing motifs. Two monomers dimerize, giving rise to a stable dimer, held together mainly by the for-mation of a continuous beta-sheet comprising eight beta-strands from two monomers. Moreover, in the structure presented two dimers aggregate to form a supramolecular organization that represents an in-activated form of the HydF maturase. The crystal structure of the latter furnishes several clues about the events necessary for cluster genera-tion/transfer, and provides an excellent model to begin elucidating the structure/function of HydF in [FeFe]-hydrogenase maturation.


===Crystal structure of the [FeFe]-hydrogenase maturation protein HydF===
Crystal structure of HydF scaffold protein provides insights into [FeFe]-hydrogenase maturation.,Cendron L, Berto P, D'Adamo S, Vallese F, Govoni C, Posewitz MC, Giacometti GM, Costantini P, Zanotti G J Biol Chem. 2011 Nov 4. PMID:22057316<ref>PMID:22057316</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_22057316}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3qq5" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 22057316 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_22057316}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3qq5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_neapolitana Thermotoga neapolitana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QQ5 OCA].
[[Category: Thermotoga neapolitana DSM 4359]]
 
[[Category: Berto P]]
==Reference==
[[Category: Cendron L]]
<ref group="xtra">PMID:022057316</ref><references group="xtra"/>
[[Category: Costantini P]]
[[Category: Thermotoga neapolitana]]
[[Category: D'Adamo S]]
[[Category: Adamo, S D.]]
[[Category: Giacometti GM]]
[[Category: Berto, P.]]
[[Category: Govoni C]]
[[Category: Cendron, L.]]
[[Category: Posewitz MC]]
[[Category: Costantini, P.]]
[[Category: Vallese F]]
[[Category: Giacometti, G M.]]
[[Category: Zanotti G]]
[[Category: Govoni, C.]]
[[Category: Posewitz, M C.]]
[[Category: Vallese, F.]]
[[Category: Zanotti, G.]]
[[Category: Gtp-binding domain]]
[[Category: H-cluster]]
[[Category: Hyda maturation]]
[[Category: Hydrogenase]]
[[Category: Maturation enzyme]]
[[Category: Oxidoreductase]]

Latest revision as of 10:22, 6 November 2024

Crystal structure of the [FeFe]-hydrogenase maturation protein HydF

3qq5, resolution 2.99Å

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