3o40: Difference between revisions

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[[Image:3o40.png|left|200px]]


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==Complex of a chimeric alpha/beta-peptide based on the gp41 CHR domain bound to gp41-5==
The line below this paragraph, containing "STRUCTURE_3o40", creates the "Structure Box" on the page.
<StructureSection load='3o40' size='340' side='right'caption='[[3o40]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3o40]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O40 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=B3E:(3S)-3-AMINOHEXANEDIOIC+ACID'>B3E</scene>, <scene name='pdbligand=B3T:3-AMINO-2,3,5-TRIDEOXY-D-THREO-PENTONIC+ACID'>B3T</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=XCP:(1S,2S)-2-AMINOCYCLOPENTANECARBOXYLIC+ACID'>XCP</scene>, <scene name='pdbligand=XPC:(3S,4R)-4-AMINOPYRROLIDINE-3-CARBOXYLIC+ACID'>XPC</scene></td></tr>
{{STRUCTURE_3o40|  PDB=3o40  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o40 OCA], [https://pdbe.org/3o40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o40 RCSB], [https://www.ebi.ac.uk/pdbsum/3o40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o40 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Infection of cells by HIV depends upon profound structural rearrangements within the trimeric viral protein gp41. Critical to this process is the formation of a six-helix bundle in which a set of three N-terminal heptad repeat (NHR) helices assemble to form a core displaying long grooves that provide docking sites for three C-terminal heptad repeat (CHR) helices. We report experiments designed to discriminate between two alternative hypotheses regarding the source of affinity between individual CHR helices and the complementary groove: (1) affinity is dominated by interactions of a small cluster of side chains at one end of the CHR helix; or (2) affinity depends upon interactions distributed across the long CHR helix. We have employed two complementary experimental designs, and results from both favor the latter hypothesis.


===Complex of a chimeric alpha/beta-peptide based on the gp41 CHR domain bound to gp41-5===
Broad Distribution of Energetically Important Contacts across an Extended Protein Interface.,Johnson LM, Horne WS, Gellman SH J Am Chem Soc. 2011 Jul 6;133(26):10038-41. Epub 2011 Jun 14. PMID:21644542<ref>PMID:21644542</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3o40" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 21644542 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21644542}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3o40]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O40 OCA].
 
==Reference==
<ref group="xtra">PMID:021644542</ref><references group="xtra"/>
[[Category: Synthetic construct]]
[[Category: Synthetic construct]]
[[Category: Gellman, S H.]]
[[Category: Gellman SH]]
[[Category: Horne, W S.]]
[[Category: Horne WS]]
[[Category: Johnson, L M.]]
[[Category: Johnson LM]]
[[Category: Hiv fusion inhibitor]]
[[Category: Mixed alpha-peptide/beta-peptide backbone]]
[[Category: Viral protein]]

Latest revision as of 09:27, 6 September 2023

Complex of a chimeric alpha/beta-peptide based on the gp41 CHR domain bound to gp41-5

3o40, resolution 2.10Å

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