3u5j: Difference between revisions

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[[Image:3u5j.jpg|left|200px]]


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==Crystal Structure of the first bromodomain of human BRD4 in complex with Alprazolam==
The line below this paragraph, containing "STRUCTURE_3u5j", creates the "Structure Box" on the page.
<StructureSection load='3u5j' size='340' side='right'caption='[[3u5j]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3u5j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U5J FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=08H:8-CHLORO-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPINE'>08H</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
{{STRUCTURE_3u5j|  PDB=3u5j  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u5j OCA], [https://pdbe.org/3u5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u5j RCSB], [https://www.ebi.ac.uk/pdbsum/3u5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u5j ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>  
== Function ==
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).


===Crystal Structure of the first bromodomain of human BRD4 in complex with Alprazolam===
==See Also==
 
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
 
== References ==
==About this Structure==
<references/>
[[3u5j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U5J OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Delft, F von.]]
[[Category: Bountra C]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Fedorov, O.]]
[[Category: Fedorov O]]
[[Category: Felletar, I.]]
[[Category: Felletar I]]
[[Category: Filippakopoulos, P.]]
[[Category: Filippakopoulos P]]
[[Category: Knapp, S.]]
[[Category: Knapp S]]
[[Category: Picaud, S.]]
[[Category: Picaud S]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: Brd4]]
[[Category: Bromodomain containing protein 4]]
[[Category: Bromodomain-containing protein 4 isoform long]]
[[Category: Cap]]
[[Category: Hunk1]]
[[Category: Mcap]]
[[Category: Mitotic chromosome associated protein]]
[[Category: Sgc]]
[[Category: Signaling protein-inhibitor complex]]
[[Category: Structural genomics consortium]]
Retrieved from "https://proteopedia.org/3u5j"