3zw6: Difference between revisions

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[[Image:3zw6.png|left|200px]]


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==MODEL OF HEXAMERIC AAA DOMAIN ARRANGEMENT OF GREEN-TYPE RUBISCO ACTIVASE FROM TOBACCO.==
The line below this paragraph, containing "STRUCTURE_3zw6", creates the "Structure Box" on the page.
<SX load='3zw6' size='340' side='right' viewer='molstar' caption='[[3zw6]], [[Resolution|resolution]] 20.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3zw6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZW6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 20&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zw6 OCA], [https://pdbe.org/3zw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zw6 RCSB], [https://www.ebi.ac.uk/pdbsum/3zw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zw6 ProSAT]</span></td></tr>
{{STRUCTURE_3zw6|  PDB=3zw6  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/RCA1_TOBAC RCA1_TOBAC] Activation of RuBisCO (ribulose-1,5-bisphosphate carboxylase/oxygenase; EC 4.1.1.39) involves the ATP-dependent carboxylation of the epsilon-amino group of lysine leading to a carbamate structure.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Rubisco, the enzyme that catalyzes the fixation of atmospheric CO(2) in photosynthesis, is subject to inactivation by inhibitory sugar phosphates. Here we report the 2.95-A crystal structure of Nicotiana tabacum Rubisco activase (Rca), the enzyme that facilitates the removal of these inhibitors. Rca from tobacco has a classical AAA(+)-protein domain architecture. Although Rca populates a range of oligomeric states when in solution, it forms a helical arrangement with six subunits per turn when in the crystal. However, negative-stain electron microscopy of the active mutant R294V suggests that Rca functions as a hexamer. The residues determining species specificity for Rubisco are located in a helical insertion of the C-terminal domain and probably function in conjunction with the N-domain in Rubisco recognition. Loop segments exposed toward the central pore of the hexamer are required for the ATP-dependent remodeling of Rubisco, resulting in the release of inhibitory sugar.


===MODEL OF HEXAMERIC AAA DOMAIN ARRANGEMENT OF GREEN-TYPE RUBISCO ACTIVASE FROM TOBACCO.===
Structure of green-type Rubisco activase from tobacco.,Stotz M, Mueller-Cajar O, Ciniawsky S, Wendler P, Hartl FU, Bracher A, Hayer-Hartl M Nat Struct Mol Biol. 2011 Nov 6. doi: 10.1038/nsmb.2171. PMID:22056769<ref>PMID:22056769</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3zw6" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_22056769}}, adds the Publication Abstract to the page
*[[RuBisCO 3D structures|RuBisCO 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 22056769 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_22056769}}
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</SX>
==About this Structure==
[[Category: Large Structures]]
[[3zw6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZW6 OCA].
 
==Reference==
<ref group="xtra">PMID:022056769</ref><references group="xtra"/>
[[Category: Nicotiana tabacum]]
[[Category: Nicotiana tabacum]]
[[Category: Bracher, A.]]
[[Category: Bracher A]]
[[Category: Ciniawsky, S.]]
[[Category: Ciniawsky S]]
[[Category: Hartl, F U.]]
[[Category: Hartl FU]]
[[Category: Hayer-Hartl, M.]]
[[Category: Hayer-Hartl M]]
[[Category: Mueller-Cajar, O.]]
[[Category: Mueller-Cajar O]]
[[Category: Stotz, M.]]
[[Category: Stotz M]]
[[Category: Wendler, P.]]
[[Category: Wendler P]]
[[Category: Negative stain em]]
[[Category: Photosynthesis]]
Retrieved from "https://proteopedia.org/3zw6"