3vh0: Difference between revisions

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[[Image:3vh0.png|left|200px]]


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==Crystal structure of E. coli YncE complexed with DNA==
The line below this paragraph, containing "STRUCTURE_3vh0", creates the "Structure Box" on the page.
<StructureSection load='3vh0' size='340' side='right'caption='[[3vh0]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3vh0]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VH0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vh0 OCA], [https://pdbe.org/3vh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vh0 RCSB], [https://www.ebi.ac.uk/pdbsum/3vh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vh0 ProSAT]</span></td></tr>
{{STRUCTURE_3vh0|  PDB=3vh0  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/YNCE_ECOLI YNCE_ECOLI]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
beta-Propellers are widely utilized in nature as recognition modules. The well conserved beta-propeller fold exhibits a high degree of functional diversity, which is probably accomplished through variations in the surface properties of the proteins. Little is known about the interactions between beta-propeller proteins and nucleic acids. In the present study, it has been found that the bacterial beta-propeller protein YncE binds to DNA. Crystal structures of YncE in the free form and complexed with DNA revealed that the surface region of YncE corresponding to the `canonical' substrate-binding site forms essential contacts with DNA. A single DNA base within a single-stranded DNA region is trapped in the hydrophobic pocket located within the central channel of the beta-propeller protein. These data provide physical evidence for the DNA-binding ability of the previously uncharacterized YncE and also suggest that the `canonical' substrate-binding site may be commonly adapted to facilitate nucleic acid binding in a subset of beta-propeller proteins.


===Crystal structure of E. coli YncE complexed with DNA===
Structural basis for the DNA-binding activity of the bacterial beta-propeller protein YncE.,Kagawa W, Sagawa T, Niki H, Kurumizaka H Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):1045-53. Epub 2011, Nov 5. PMID:22120742<ref>PMID:22120742</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3vh0" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 22120742 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_22120742}}
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</StructureSection>
==About this Structure==
[[Category: Escherichia coli K-12]]
[[3vh0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VH0 OCA].
[[Category: Large Structures]]
 
[[Category: Kagawa W]]
==Reference==
[[Category: Kurumizaka H]]
<ref group="xtra">PMID:022120742</ref><references group="xtra"/>
[[Category: Niki H]]
[[Category: Escherichia coli]]
[[Category: Sagawa T]]
[[Category: Kagawa, W.]]
[[Category: Kurumizaka, H.]]
[[Category: Niki, H.]]
[[Category: Sagawa, T.]]
[[Category: Beta-propeller]]
[[Category: Protein binding-dna complex]]
Retrieved from "https://proteopedia.org/3vh0"