3uk3: Difference between revisions

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'''Unreleased structure'''


The entry 3uk3 is ON HOLD  until Paper Publication
==Crystal structure of ZNF217 bound to DNA==
 
<StructureSection load='3uk3' size='340' side='right'caption='[[3uk3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
Authors: Vandevenne, M.S., Jacques, D.A., Guss, J.M., Mackay, J.P.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3uk3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UK3 FirstGlance]. <br>
Description: Crystal structure of ZNF217 bound to DNA
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uk3 OCA], [https://pdbe.org/3uk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uk3 RCSB], [https://www.ebi.ac.uk/pdbsum/3uk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uk3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ZN217_HUMAN ZN217_HUMAN] Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.<ref>PMID:16203743</ref> <ref>PMID:17259635</ref> <ref>PMID:18625718</ref> <ref>PMID:16940172</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Guss JM]]
[[Category: Jacques DA]]
[[Category: Mackay JP]]
[[Category: Vandevenne MS]]
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