3uwk: Difference between revisions
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==Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation== | |||
<StructureSection load='3uwk' size='340' side='right'caption='[[3uwk]], [[Resolution|resolution]] 1.91Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3uwk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UWK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DF:1-METHYL-6-PHENYL-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE'>0DF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwk OCA], [https://pdbe.org/3uwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uwk RCSB], [https://www.ebi.ac.uk/pdbsum/3uwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uwk ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KTHY_PSEAE KTHY_PSEAE] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity). | |||
==See Also== | |||
*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pseudomonas aeruginosa PAO1]] | |||
[[Category: Chang J]] | |||
[[Category: Choi JY]] | |||
[[Category: Desbonnet CR]] | |||
[[Category: Dillman K]] | |||
[[Category: Miller AA]] | |||
[[Category: Miller JR]] | |||
[[Category: Plummer MS]] | |||
[[Category: Roush WR]] | |||
[[Category: Soutter HH]] | |||
[[Category: Starr J]] | |||
Latest revision as of 10:29, 1 March 2024
Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation
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