3u50: Difference between revisions

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==Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 OB-C==
The line below this paragraph, containing "STRUCTURE_3u50", creates the "Structure Box" on the page.
<StructureSection load='3u50' size='340' side='right'caption='[[3u50]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3u50]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U50 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3u50|  PDB=3u50  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u50 OCA], [https://pdbe.org/3u50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u50 RCSB], [https://www.ebi.ac.uk/pdbsum/3u50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u50 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TEB1_TETTS TEB1_TETTS] Single-stranded DNA (ssDNA)-binding protein that mediates the recruitment of telomerase to telomeric DNA (PubMed:19941821, PubMed:20363756, PubMed:25225329, PubMed:22143754). Telomerase is an essential ribonucleoprotein (RNP) enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:19941821). Acts as part of a replication protein A (RPA)-related subcomplex of the holoenzyme telomerase ribonucleoprotein complex: TEB1 specifically recognizes and binds telomeric ssDNA, thereby mediating the recruitment of the holoenzyme telomerase RNP complex to telomeres (PubMed:19941821, PubMed:25225329, PubMed:27895115). TEB1 is related to RPA1 subunit of the RPA complex but is specific to telomeric DNA, which is not the case of RPA1 (PubMed:25225329).<ref>PMID:19941821</ref> <ref>PMID:20363756</ref> <ref>PMID:22143754</ref> <ref>PMID:25225329</ref> <ref>PMID:27895115</ref>  


===Crystal Structure of the Tetrahymena telomerase processivity factor Teb1 OB-C===
==See Also==
 
*[[Telomerase-associated protein|Telomerase-associated protein]]
 
== References ==
==About this Structure==
<references/>
[[3u50]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U50 OCA].
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Tetrahymena thermophila]]
[[Category: Tetrahymena thermophila]]
[[Category: Huang, J.]]
[[Category: Huang J]]
[[Category: Lei, M.]]
[[Category: Lei M]]
[[Category: Yang, Y.]]
[[Category: Yang Y]]
[[Category: Zeng, Z.]]
[[Category: Zeng Z]]
[[Category: Dna binding protein]]
[[Category: Processivity factor]]
[[Category: Teb1]]
[[Category: Telomerase]]
[[Category: Tetrahymena]]
Retrieved from "https://proteopedia.org/3u50"