3t6a: Difference between revisions

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[[Image:3t6a.png|left|200px]]


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==Structure of the C-terminal domain of BCAR3==
The line below this paragraph, containing "STRUCTURE_3t6a", creates the "Structure Box" on the page.
<StructureSection load='3t6a' size='340' side='right'caption='[[3t6a]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3t6a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T6A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=POG:(20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL'>POG</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
{{STRUCTURE_3t6a|  PDB=3t6a  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t6a OCA], [https://pdbe.org/3t6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t6a RCSB], [https://www.ebi.ac.uk/pdbsum/3t6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t6a ProSAT]</span></td></tr>
 
</table>
===Structure of the C-terminal domain of BCAR3===
== Function ==
 
[https://www.uniprot.org/uniprot/BCAR3_HUMAN BCAR3_HUMAN] May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins.<ref>PMID:9582273</ref>  
 
== References ==
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{{ABSTRACT_PUBMED_22081014}}
 
==About this Structure==
[[3t6a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T6A OCA].  
 
==Reference==
<ref group="xtra">PMID:022081014</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Mace, P D.]]
[[Category: Large Structures]]
[[Category: Riedl, S J.]]
[[Category: Mace PD]]
[[Category: Robinson, H.]]
[[Category: Riedl SJ]]
[[Category: Cdc25-homology domain]]
[[Category: Robinson H]]
[[Category: Gtpase exchange factor]]
[[Category: Signaling protein]]

Latest revision as of 10:04, 1 March 2024

Structure of the C-terminal domain of BCAR3

3t6a, resolution 2.40Å

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