3twq: Difference between revisions

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[[Image:3twq.png|left|200px]]


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==Crystal structure of ARC4 from human Tankyrase 2 (apo form)==
The line below this paragraph, containing "STRUCTURE_3twq", creates the "Structure Box" on the page.
<StructureSection load='3twq' size='340' side='right'caption='[[3twq]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3twq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TWQ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.151&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3twq|  PDB=3twq  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3twq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3twq OCA], [https://pdbe.org/3twq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3twq RCSB], [https://www.ebi.ac.uk/pdbsum/3twq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3twq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>  


===Crystal structure of ARC4 from human Tankyrase 2 (apo form)===
==See Also==
 
*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
 
== References ==
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{{ABSTRACT_PUBMED_22153077}}
 
==About this Structure==
[[3twq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TWQ OCA].
 
==Reference==
<ref group="xtra">PMID:022153077</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Guettler, S.]]
[[Category: Large Structures]]
[[Category: Sicheri, F.]]
[[Category: Guettler S]]
[[Category: Ankyrin repeat]]
[[Category: Sicheri F]]
[[Category: Protein-protein interaction]]
[[Category: Signaling protein]]
[[Category: Substrate recruitment]]
Retrieved from "https://proteopedia.org/3twq"