3oai: Difference between revisions

Latest revision as of 09:30, 30 October 2024

Crystal structure of the extra-cellular domain of human myelin protein zero

Structural highlights

3oai is a 2 chain structure with sequence from Escherichia coli and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.1Å
Ligands:	GLC, PRD_900001
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

MYP0_HUMAN Palmoplantar keratoderma-hereditary motor and sensory neuropathy syndrome;Autosomal dominant intermediate Charcot-Marie-Tooth disease type D;Autosomal dominant Charcot-Marie-Tooth disease type 2I;Roussy-Levy syndrome;Autosomal dominant intermediate Charcot-Marie-Tooth disease with neuropathic pain;Dejerine-Sottas syndrome;Charcot-Marie-Tooth disease type 1B;Autosomal dominant Charcot-Marie-Tooth disease type 2J. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease may be caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.

Function

MALE_ECOLI Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.MYP0_HUMAN Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.^[1] ^[2]

References

↑ Lagueny A, Latour P, Vital A, Rajabally Y, Le Masson G, Ferrer X, Bernard I, Julien J, Vital C, Vandenberghe A. Peripheral myelin modification in CMT1B correlates with MPZ gene mutations. Neuromuscul Disord. 1999 Oct;9(6-7):361-7. PMID:10545037 doi:10.1016/s0960-8966(99)00031-0
↑ Grandis M, Vigo T, Passalacqua M, Jain M, Scazzola S, La Padula V, Brucal M, Benvenuto F, Nobbio L, Cadoni A, Mancardi GL, Kamholz J, Shy ME, Schenone A. Different cellular and molecular mechanisms for early and late-onset myelin protein zero mutations. Hum Mol Genet. 2008 Jul 1;17(13):1877-89. PMID:18337304 doi:10.1093/hmg/ddn083

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Lagueny A, Latour P, Vital A, Rajabally Y, Le Masson G, Ferrer X, Bernard I, Julien J, Vital C, Vandenberghe A. Peripheral myelin modification in CMT1B correlates with MPZ gene mutations. Neuromuscul Disord. 1999 Oct;9(6-7):361-7. PMID:10545037 doi:10.1016/s0960-8966(99)00031-0

[2] Grandis M, Vigo T, Passalacqua M, Jain M, Scazzola S, La Padula V, Brucal M, Benvenuto F, Nobbio L, Cadoni A, Mancardi GL, Kamholz J, Shy ME, Schenone A. Different cellular and molecular mechanisms for early and late-onset myelin protein zero mutations. Hum Mol Genet. 2008 Jul 1;17(13):1877-89. PMID:18337304 doi:10.1093/hmg/ddn083

[1]

[2]

@@ Line 1: / Line 1: @@
-[[Image:3oai.png|left|200px]]
-<!--
+==Crystal structure of the extra-cellular domain of human myelin protein zero==
-The line below this paragraph, containing "STRUCTURE_3oai", creates the "Structure Box" on the page.
+<StructureSection load='3oai' size='340' side='right'caption='[[3oai]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3oai]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OAI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OAI FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
-{{STRUCTURE_3oai|  PDB=3oai  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oai OCA], [https://pdbe.org/3oai PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oai RCSB], [https://www.ebi.ac.uk/pdbsum/3oai PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oai ProSAT]</span></td></tr>
+</table>
-===Crystal structure of the extra-cellular domain of human myelin protein zero===
+== Disease ==
+[https://www.uniprot.org/uniprot/MYP0_HUMAN MYP0_HUMAN] Palmoplantar keratoderma-hereditary motor and sensory neuropathy syndrome;Autosomal dominant intermediate Charcot-Marie-Tooth disease type D;Autosomal dominant Charcot-Marie-Tooth disease type 2I;Roussy-Levy syndrome;Autosomal dominant intermediate Charcot-Marie-Tooth disease with neuropathic pain;Dejerine-Sottas syndrome;Charcot-Marie-Tooth disease type 1B;Autosomal dominant Charcot-Marie-Tooth disease type 2J. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease may be caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
-==About this Structure==
+[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/MYP0_HUMAN MYP0_HUMAN] Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.<ref>PMID:10545037</ref> <ref>PMID:18337304</ref>
-[[3oai]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli,_homo_sapiens Escherichia coli, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OAI OCA].
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:021971831</ref><references group="xtra"/>
+</StructureSection>
-[[Category: Escherichia coli, homo sapiens]]
+[[Category: Escherichia coli]]
-[[Category: Brunzelle, J.]]
+[[Category: Homo sapiens]]
-[[Category: Kamholz, J.]]
+[[Category: Large Structures]]
-[[Category: Kovari, I A.]]
+[[Category: Brunzelle J]]
-[[Category: Kovari, L C.]]
+[[Category: Kamholz J]]
-[[Category: Liu, Z.]]
+[[Category: Kovari IA]]
-[[Category: Sohi, J.]]
+[[Category: Kovari LC]]
-[[Category: Wang, Y.]]
+[[Category: Liu Z]]
-[[Category: Cell adhesion]]
+[[Category: Sohi J]]
-[[Category: Immunoglobulin-folding]]
+[[Category: Wang Y]]
-[[Category: Intercelluar adhesion]]
-[[Category: Membrane protein]]
-[[Category: Schwann cell membrane protein]]
-[[Category: Tetramer]]

3oai: Difference between revisions

Latest revision as of 09:30, 30 October 2024

Crystal structure of the extra-cellular domain of human myelin protein zero

Structural highlights

Disease

Function

References

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