3v1w: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 3v1w is ~~ON HOLD~~

==Molecular Basis for Multiple Ligand Binding of Calsequestrin and Potential Inhibition by Caffeine and Gallocatecin==

~~Authors~~: ~~Subramanian~~, A.K., ~~Nissen, M~~.N., ~~Lewis~~, K.M., ~~Sanchez~~, E.J., ~~Muralidharan~~, A.K., Kang, C

== Structural highlights ==

<table><tr><td colspan='2'>[[3v1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V1W OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=3V1W FirstGlance].

~~Description~~: ~~Molecular Basis for Multiple Ligand Binding of Calsequestrin and Potential Inhibition by Caffeine and Gallocatecin~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.908Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=3v1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v1w OCA], [https://pdbe.org/3v1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v1w RCSB], [https://www.ebi.ac.uk/pdbsum/3v1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v1w ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/CASQ1_RABIT CASQ1_RABIT] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions (By similarity).

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Oryctolagus cuniculus]]

[[Category: Kang C]]

[[Category: Lewis KM]]

[[Category: Muralidharan AK]]

[[Category: Nissen MN]]

[[Category: Sanchez EJ]]

[[Category: Subramanian AK]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 3v1w is ON HOLD
+==Molecular Basis for Multiple Ligand Binding of Calsequestrin and Potential Inhibition by Caffeine and Gallocatecin==
+<StructureSection load='3v1w' size='340' side='right'caption='[[3v1w]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
-Authors: Subramanian, A.K., Nissen, M.N., Lewis, K.M., Sanchez, E.J., Muralidharan, A.K., Kang, C
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3v1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V1W FirstGlance]. <br>
-Description: Molecular Basis for Multiple Ligand Binding of Calsequestrin and Potential Inhibition by Caffeine and Gallocatecin
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.908&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v1w OCA], [https://pdbe.org/3v1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v1w RCSB], [https://www.ebi.ac.uk/pdbsum/3v1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v1w ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CASQ1_RABIT CASQ1_RABIT] Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Oryctolagus cuniculus]]
+[[Category: Kang C]]
+[[Category: Lewis KM]]
+[[Category: Muralidharan AK]]
+[[Category: Nissen MN]]
+[[Category: Sanchez EJ]]
+[[Category: Subramanian AK]]