3v6e: Difference between revisions

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New page: '''Unreleased structure''' The entry 3v6e is ON HOLD Authors: Neculai, M., Ernst, A., Sidhu, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Dhe-Paganon, S., Structural G...
 
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'''Unreleased structure'''


The entry 3v6e is ON HOLD
==Crystal Structure of USP2 and a mutant form of Ubiquitin==
<StructureSection load='3v6e' size='340' side='right'caption='[[3v6e]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3v6e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6E FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6e OCA], [https://pdbe.org/3v6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6e RCSB], [https://www.ebi.ac.uk/pdbsum/3v6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UBP2_HUMAN UBP2_HUMAN] Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells.<ref>PMID:17290220</ref> <ref>PMID:19917254</ref> <ref>PMID:19838211</ref>


Authors: Neculai, M., Ernst, A., Sidhu, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
==See Also==
 
*[[Thioesterase 3D structures|Thioesterase 3D structures]]
Description: Crystal Structure of USP2 and a mutant form of Ubiquitin
*[[3D structures of ubiquitin|3D structures of ubiquitin]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Dhe-Paganon S]]
[[Category: Edwards AM]]
[[Category: Ernst A]]
[[Category: Neculai M]]
[[Category: Sidhu S]]
[[Category: Weigelt J]]
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