3uhd: Difference between revisions

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[[Image:3uhd.jpg|left|200px]]


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==HBI (N100A) CO bound==
The line below this paragraph, containing "STRUCTURE_3uhd", creates the "Structure Box" on the page.
<StructureSection load='3uhd' size='340' side='right'caption='[[3uhd]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3uhd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anadara_inaequivalvis Anadara inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UHD FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
{{STRUCTURE_3uhd|  PDB=3uhd  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uhd OCA], [https://pdbe.org/3uhd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uhd RCSB], [https://www.ebi.ac.uk/pdbsum/3uhd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uhd ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLB1_ANAIN GLB1_ANAIN]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Here we present a meta-analysis of a large collection of static structures of a protein in the Protein Data Bank in order to extract the progression of structural events during protein function. We apply this strategy to the homodimeric hemoglobin HbI from Scapharca inaequivalvis. We derive a simple dynamic model describing how binding of the first ligand in one of the two chemically identical subunits facilitates a second binding event in the other partner subunit. The results of our ultrafast time-resolved crystallographic studies support this model. We demonstrate that HbI functions like a homodimeric mechanical device, such as pliers or scissors. Ligand-induced motion originating in one subunit is transmitted to the other via conserved pivot points, where the E and F' helices from two partner subunits are "bolted" together to form a stable dimer interface permitting slight relative rotation but preventing sliding.


===HBI (N100A) CO bound===
Cooperative macromolecular device revealed by meta-analysis of static and time-resolved structures.,Ren Z, Srajer V, Knapp JE, Royer WE Jr Proc Natl Acad Sci U S A. 2011 Dec 14. PMID:22171006<ref>PMID:22171006</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3uhd" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_22171006}}, adds the Publication Abstract to the page
*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 22171006 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_22171006}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Anadara inaequivalvis]]
[[3uhd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scapharca_inaequivalvis Scapharca inaequivalvis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UHD OCA].
[[Category: Large Structures]]
 
[[Category: Knapp JE]]
==Reference==
[[Category: Ren Z]]
<ref group="xtra">PMID:022171006</ref><references group="xtra"/>
[[Category: Royer Jr WE]]
[[Category: Scapharca inaequivalvis]]
[[Category: Srajer V]]
[[Category: Knapp, J E.]]
[[Category: Ren, Z.]]
[[Category: Royer, W E.]]
[[Category: Srajer, V.]]
[[Category: Allostery]]
[[Category: Oxygen binding]]
[[Category: Oxygen storage]]
[[Category: Oxygen transport]]
Retrieved from "https://proteopedia.org/3uhd"