3u1y: Difference between revisions

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[[Image:3u1y.jpg|left|200px]]


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==Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections==
The line below this paragraph, containing "STRUCTURE_3u1y", creates the "Structure Box" on the page.
<StructureSection load='3u1y' size='340' side='right'caption='[[3u1y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3u1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U1Y FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=03I:(2R)-N-HYDROXY-2-METHYL-2-(METHYLSULFONYL)-4-{4-[3-(MORPHOLIN-4-YL)PROPOXY]BIPHENYL-4-YL}BUTANAMIDE'>03I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3u1y|  PDB=3u1y  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u1y OCA], [https://pdbe.org/3u1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u1y RCSB], [https://www.ebi.ac.uk/pdbsum/3u1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u1y ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


===Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections===
==See Also==
 
*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
 
*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase 3D structures|UDP-3-O-acyl-N-acetylglucosamine deacetylase 3D structures]]
<!--  
__TOC__
The line below this paragraph, {{ABSTRACT_PUBMED_22175825}}, adds the Publication Abstract to the page
</StructureSection>
(as it appears on PubMed at http://www.pubmed.gov), where 22175825 is the PubMed ID number.
[[Category: Large Structures]]
-->
{{ABSTRACT_PUBMED_22175825}}
 
==About this Structure==
[[3u1y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U1Y OCA].
 
==Reference==
<ref group="xtra">PMID:022175825</ref><references group="xtra"/>
[[Category: Pseudomonas aeruginosa]]
[[Category: Abramite, J.]]
[[Category: Brown, M.]]
[[Category: Liu, S.]]
[[Category: Gram negative]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Lpxc]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Abramite J]]
[[Category: Brown M]]
[[Category: Liu S]]

Latest revision as of 13:45, 14 March 2024

Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections

3u1y, resolution 2.00Å

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