3ugm: Difference between revisions

Latest revision as of 10:23, 1 March 2024

Structure of TAL effector PthXo1 bound to its DNA target

Structural highlights

3ugm is a 3 chain structure with sequence from Xanthomonas oryzae pv. oryzae PXO99A. The December 2014 RCSB PDB Molecule of the Month feature on TAL Effectors by David Goodsell is 10.2210/rcsb_pdb/mom_2014_12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PTHX1_XANOP Avirulence protein. Acts as a transcription factor in rice, inducing expression of a number of host genes including SWEET11 (Os8N3, XA13, AC Q6YZF3) in susceptible plants with the Xa13 allele. Plants with the xa13 allele, which has an altered promoter, are resistant to bacterial blight caused by this bacterial strain and do not induce SWEET11. The xa13 allele elicits an atypical hypersensitive response (HR). PthXo1 binds SWEET11 promoter DNA in a sequence-specific manner.^[1] ^[2] ^[3] ^[4]

References

↑ Yang B, White FF. Diverse members of the AvrBs3/PthA family of type III effectors are major virulence determinants in bacterial blight disease of rice. Mol Plant Microbe Interact. 2004 Nov;17(11):1192-200. PMID:15553245 doi:10.1094/MPMI.2004.17.11.1192
↑ Yang B, Sugio A, White FF. Os8N3 is a host disease-susceptibility gene for bacterial blight of rice. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10503-10508. PMID:16798873 doi:10.1073/pnas.0604088103
↑ Römer P, Recht S, Strauß T, Elsaesser J, Schornack S, Boch J, Wang S, Lahaye T. Promoter elements of rice susceptibility genes are bound and activated by specific TAL effectors from the bacterial blight pathogen, Xanthomonas oryzae pv. oryzae. New Phytol. 2010 Sep;187(4):1048-1057. PMID:20345643 doi:10.1111/j.1469-8137.2010.03217.x
↑ Mak AN, Bradley P, Cernadas RA, Bogdanove AJ, Stoddard BL. The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target. Science. 2012 Jan 5. PMID:22223736 doi:10.1126/science.1216211

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OCA

[1] Yang B, White FF. Diverse members of the AvrBs3/PthA family of type III effectors are major virulence determinants in bacterial blight disease of rice. Mol Plant Microbe Interact. 2004 Nov;17(11):1192-200. PMID:15553245 doi:10.1094/MPMI.2004.17.11.1192

[2] Yang B, Sugio A, White FF. Os8N3 is a host disease-susceptibility gene for bacterial blight of rice. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10503-10508. PMID:16798873 doi:10.1073/pnas.0604088103

[3] Römer P, Recht S, Strauß T, Elsaesser J, Schornack S, Boch J, Wang S, Lahaye T. Promoter elements of rice susceptibility genes are bound and activated by specific TAL effectors from the bacterial blight pathogen, Xanthomonas oryzae pv. oryzae. New Phytol. 2010 Sep;187(4):1048-1057. PMID:20345643 doi:10.1111/j.1469-8137.2010.03217.x

[4] Mak AN, Bradley P, Cernadas RA, Bogdanove AJ, Stoddard BL. The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target. Science. 2012 Jan 5. PMID:22223736 doi:10.1126/science.1216211

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-[[Image:3ugm.png|left|200px]]
-<!--
+==Structure of TAL effector PthXo1 bound to its DNA target==
-The line below this paragraph, containing "STRUCTURE_3ugm", creates the "Structure Box" on the page.
+<StructureSection load='3ugm' size='340' side='right'caption='[[3ugm]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ugm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_oryzae_pv._oryzae_PXO99A Xanthomonas oryzae pv. oryzae PXO99A]. The December 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''TAL Effectors''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_12 10.2210/rcsb_pdb/mom_2014_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UGM FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ugm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ugm OCA], [https://pdbe.org/3ugm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ugm RCSB], [https://www.ebi.ac.uk/pdbsum/3ugm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ugm ProSAT]</span></td></tr>
-{{STRUCTURE_3ugm|  PDB=3ugm  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PTHX1_XANOP PTHX1_XANOP] Avirulence protein. Acts as a transcription factor in rice, inducing expression of a number of host genes including SWEET11 (Os8N3, XA13, AC Q6YZF3) in susceptible plants with the Xa13 allele. Plants with the xa13 allele, which has an altered promoter, are resistant to bacterial blight caused by this bacterial strain and do not induce SWEET11. The xa13 allele elicits an atypical hypersensitive response (HR). PthXo1 binds SWEET11 promoter DNA in a sequence-specific manner.<ref>PMID:15553245</ref> <ref>PMID:16798873</ref> <ref>PMID:20345643</ref> <ref>PMID:22223736</ref>
-===Structure of TAL effector PthXo1 bound to its DNA target===
+==See Also==
+*[[TAL effector|TAL effector]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_22223736}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 22223736 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Large Structures]]
-{{ABSTRACT_PUBMED_22223736}}
+[[Category: RCSB PDB Molecule of the Month]]
+[[Category: TAL Effectors]]
-==About this Structure==
+[[Category: Xanthomonas oryzae pv. oryzae PXO99A]]
-[[3ugm]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_oryzae Xanthomonas oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UGM OCA].
+[[Category: Bogdanove AJ]]
+[[Category: Bradley P]]
-==Reference==
+[[Category: Cernadas RA]]
-<ref group="xtra">PMID:022223736</ref><references group="xtra"/>
+[[Category: Mak ANS]]
-[[Category: Xanthomonas oryzae]]
+[[Category: Stoddard BL]]
-[[Category: Bogdanove, A J.]]
-[[Category: Bradley, P.]]
-[[Category: Cernadas, R A.]]
-[[Category: Mak, A N.S.]]
-[[Category: Stoddard, B L.]]
-[[Category: Dna binding protein]]
-[[Category: Tal effector]]
-[[Category: Transcription-dna complex]]

3ugm: Difference between revisions

Latest revision as of 10:23, 1 March 2024

Structure of TAL effector PthXo1 bound to its DNA target

Structural highlights

Function

See Also

References

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