4dbr: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4dbr is ~~ON HOLD~~

==Myosin VI D179Y (MD) pre-powerstroke state==

== Structural highlights ==

<table><tr><td colspan='2'>[[4dbr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DBR OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4DBR FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4dbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dbr OCA], [https://pdbe.org/4dbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dbr RCSB], [https://www.ebi.ac.uk/pdbsum/4dbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dbr ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref>

~~Authors~~: ~~Pylypenko, O., Sweeney, H.L.,~~ Houdusse, A.

==See Also==

*[[Myosin 3D Structures|Myosin 3D Structures]]

~~Description~~: ~~MYOSIN VI D179Y (MD) PRE-POWERSTROKE STATE~~

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Sus scrofa]]

[[Category: Houdusse A]]

[[Category: Pylypenko O]]

[[Category: Sweeney HL]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4dbr is ON HOLD
+==Myosin VI D179Y (MD) pre-powerstroke state==
+<StructureSection load='4dbr' size='340' side='right'caption='[[4dbr]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4dbr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DBR FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dbr OCA], [https://pdbe.org/4dbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dbr RCSB], [https://www.ebi.ac.uk/pdbsum/4dbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dbr ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref>
-Authors: Pylypenko, O., Sweeney, H.L., Houdusse, A.
+==See Also==
+*[[Myosin 3D Structures|Myosin 3D Structures]]
-Description: MYOSIN VI D179Y (MD) PRE-POWERSTROKE STATE
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Sus scrofa]]
+[[Category: Houdusse A]]
+[[Category: Pylypenko O]]
+[[Category: Sweeney HL]]