3tvx: Difference between revisions

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[[Image:3tvx.jpg|left|200px]]


<!--
==The structure of PDE4A with pentoxifylline at 2.84A resolution==
The line below this paragraph, containing "STRUCTURE_3tvx", creates the "Structure Box" on the page.
<StructureSection load='3tvx' size='340' side='right'caption='[[3tvx]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3tvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TVX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.84&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PNX:3,7-DIMETHYL-1-(5-OXOHEXYL)-3,7-DIHYDRO-1H-PURINE-2,6-DIONE'>PNX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3tvx|  PDB=3tvx  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tvx OCA], [https://pdbe.org/3tvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tvx RCSB], [https://www.ebi.ac.uk/pdbsum/3tvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tvx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE4A_HUMAN PDE4A_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:11566027</ref> <ref>PMID:17727341</ref>


===The structure of PDE4A with pentoxifylline at 2.84A resolution===
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_22223051}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 22223051 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_22223051}}
 
==About this Structure==
[[3tvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TVX OCA].
 
==Reference==
<ref group="xtra">PMID:022223051</ref><references group="xtra"/>
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Badger, J.]]
[[Category: Large Structures]]
[[Category: Sridhar, V.]]
[[Category: Badger J]]
[[Category: Hydrolase]]
[[Category: Sridhar V]]
[[Category: Hydrolase-hydrolase inhibitor complex]]

Latest revision as of 13:41, 14 March 2024

The structure of PDE4A with pentoxifylline at 2.84A resolution

3tvx, resolution 2.84Å

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