Transferrin: Difference between revisions

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{{STRUCTURE_1jnf|  PDB=1jnf  | SIZE=400| SCENE= |right|CAPTION=Rabbit transferrin  [[1jnf]] }}
<StructureSection load='' size='350' side='right' caption='Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code [[3qyt]]).' scene='48/480879/Cv/1' pspeed='8'>
== Function ==
'''Transferrin''' or '''serotransferrin''' (TF) is an iron-binding protein.  TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues<ref>PMID:2208733</ref>.  '''Ovotransferrin''' (OTF) is a glycosylated TF of egg white. For details see [[Molecular Playground/Transferrin]].


'''Transferrin''' (TF) is an iron-binding protein.  TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues.  TF contains two lobes: at the N  and C termini.  Ovotransferrin (OTF) is a glycosylated TF of egg white albumen.  For details see [[Molecular Playground/Transferrin]].
== Relevance ==
Carbohydrate-deficient TF may help diagnose alcoholic liver disease<ref>PMID:15908327</ref>.


{{TOC limit|limit=2}}
== Structural highlights ==


TF contains <scene name='48/480879/Cv/7'>two lobes</scene>: at the N  and C termini.  The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions<ref>PMID:23256035</ref>.
*<scene name='48/480879/Cv/8'>N-lobe Fe coordination site</scene>.
*<scene name='48/480879/Cv/9'>C-lobe Fe coordination site</scene>.
== 3D Structures of Transferrin ==
== 3D Structures of Transferrin ==
[[Transferrin 3D structures]]


===Transferrin===
</StructureSection>
 
[[1jnf]] – rTF - rabbit<br />
[[1suv]] – hTF + TF receptor - human<br />
[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />
[[1h76]] – TF - pig
 
===Transferrin N lobe===
 
[[1tfd]] – rTF N terminal<br />
[[1a8e]], [[1a8f]], [[1b3e]], [[1n84]] - hTF N terminal<br />
[[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br />
[[1ryo]] - hTF N terminal + oxalate
 
===Apo transferrin===
 
[[1bp5]], [[1btj]] - hTF N terminal<br />
[[2hau]], [[2hav]] – hTF (mutant)
 
===Ovotransferrin===
 
[[1ovt]], [[1n04]] – cOTF - chicken<br />
[[2d3i]] – cOTF (Al)<br />
[[1dot]] – dOTF - duck
 
===Ovotransferrin N lobe===
 
[[1ovb]], [[1gv8]] – dOTF NII domain <br />
[[1gvc]] - dOTF NII domain + nitrilotriacetate<br />
[[1nnt]], [[1nft]], [[1iej]] – cOTF N terminal<br />
 
===Apo ovotransferrin===
 
[[1aov]] – dOTF<br />
[[1aiv]], [[1ryx]]– cOTF<br />
[[1tfa]] - cOTF N terminal<br />
[[1iq7]] - cOTF C terminal<br />
[[1lfc]] – OTF residues 17-41 – bovine - NMR


== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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