3tgg: Difference between revisions

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[[Image:3tgg.png|left|200px]]


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==A novel series of potent and selective PDE5 inhibitor2==
The line below this paragraph, containing "STRUCTURE_3tgg", creates the "Structure Box" on the page.
<StructureSection load='3tgg' size='340' side='right'caption='[[3tgg]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3tgg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TGG FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0H3:7-(6-METHOXYPYRIDIN-3-YL)-4-{[2-(PROPAN-2-YLOXY)ETHYL]AMINO}-1-(2-PROPOXYETHYL)PYRIDO[4,3-D]PYRIMIDIN-2(1H)-ONE'>0H3</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3tgg|  PDB=3tgg  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tgg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgg OCA], [https://pdbe.org/3tgg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tgg RCSB], [https://www.ebi.ac.uk/pdbsum/3tgg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.


===A novel series of potent and selective PDE5 inhibitor2===
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_21955943}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 21955943 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_21955943}}
 
==About this Structure==
[[3tgg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGG OCA].
 
==Reference==
<ref group="xtra">PMID:021955943</ref><references group="xtra"/>
[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Han, S.]]
[[Category: Large Structures]]
[[Category: Hydrolase]]
[[Category: Han S]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Phosphodiesterase]]

Latest revision as of 10:08, 1 March 2024

A novel series of potent and selective PDE5 inhibitor2

3tgg, resolution 1.91Å

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