Plectin: Difference between revisions

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<~~Structure~~ load='1sh6' size='~~500~~' ~~frame='true' align='right' caption='Insert~~ caption ~~here' scene~~='Mouse plectin actin-binding domain/>~~<!--~~

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== Function ==

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'''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain (residues 1492-1530), N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains (repeat#6 contains residues 4403-4606), and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin<ref>PMID:24810881</ref>, <ref>PMID:24940650</ref>. N-terminal globular region contains actin binding domain (ABD) (residues 175-400) comprising of two calponin homology (CH) domains, plakin domain (residues 300-1372) and N-terminal arm, which varies among isoforms.

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Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin ~~(2)~~. N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms ~~(3)~~.

For more details see [[Group:MUZIC:Plectin]].

==Disease ==

Mutations in plectin result in skin fragility and blister formation<ref>PMID:15810881</ref>.

</StructureSection>

==3D structures of plectin==

[[Plectin 3D structures]]

== References ==

[[Category:Topic Page]]

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@@ Line 1: / Line 1: @@
-<Structure load='1sh6' size='500' frame='true' align='right' caption='Insert caption here' scene='Mouse  plectin actin-binding domain/><!--
+<StructureSection load='1sh6' size='400'  caption='Mouse plectin actin-binding domain [[1sh6]]' scene= '>
-Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
+== Function ==
-Or use the four-green-boxes-button to insert scrollable text adjacent
+'''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain (residues 1492-1530), N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains (repeat#6 contains residues 4403-4606), and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin<ref>PMID:24810881</ref>, <ref>PMID:24940650</ref>. N-terminal globular region contains actin binding domain (ABD) (residues 175-400) comprising of two calponin homology (CH) domains, plakin domain (residues 300-1372) and N-terminal arm, which varies among isoforms.
-to a Jmol applet. Check out the other buttons as well!
--->
-Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3).
+For more details see [[Group:MUZIC:Plectin]].
+==Disease ==
+Mutations in plectin result in skin fragility and blister formation<ref>PMID:15810881</ref>.
+</StructureSection>
+==3D structures of plectin==
+[[Plectin 3D structures]]
+== References ==
 <references/>
+[[Category:Topic Page]]