3uvn: Difference between revisions

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[[Image:3uvn.png|left|200px]]


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==Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A==
The line below this paragraph, containing "STRUCTURE_3uvn", creates the "Structure Box" on the page.
<StructureSection load='3uvn' size='340' side='right'caption='[[3uvn]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3uvn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UVN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.792&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uvn OCA], [https://pdbe.org/3uvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uvn RCSB], [https://www.ebi.ac.uk/pdbsum/3uvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uvn ProSAT]</span></td></tr>
{{STRUCTURE_3uvn|  PDB=3uvn  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/SET1A_HUMAN SET1A_HUMAN] Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.<ref>PMID:12670868</ref>  


===Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A===
==See Also==
 
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
 
== References ==
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 22266653 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_22266653}}
 
==About this Structure==
[[3uvn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UVN OCA].
 
==Reference==
<ref group="xtra">PMID:022266653</ref><references group="xtra"/>
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Brunzelle, J S.]]
[[Category: Large Structures]]
[[Category: Couture, J F.]]
[[Category: Brunzelle JS]]
[[Category: Lee, H.]]
[[Category: Couture J-F]]
[[Category: Zhang, P.]]
[[Category: Lee H]]
[[Category: Beta-propeller]]
[[Category: Zhang P]]
[[Category: Chromatin biology]]
[[Category: Histone h3]]
[[Category: Nucleus]]
[[Category: Scaffolding]]
[[Category: Transcription]]
[[Category: Trithorax]]
Retrieved from "https://proteopedia.org/3uvn"