3trw: Difference between revisions

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[[Image:3trw.png|left|200px]]


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==Crystal structure of racemic villin headpiece subdomain crystallized in space group P-1==
The line below this paragraph, containing "STRUCTURE_3trw", creates the "Structure Box" on the page.
<StructureSection load='3trw' size='340' side='right'caption='[[3trw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3trw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TRW FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3trw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3trw OCA], [https://pdbe.org/3trw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3trw RCSB], [https://www.ebi.ac.uk/pdbsum/3trw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3trw ProSAT]</span></td></tr>
{{STRUCTURE_3trw|  PDB=3trw  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/VILI_CHICK VILI_CHICK] Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity). Its actin-bundling activity is inhibited by tropomyosin.<ref>PMID:3793760</ref> <ref>PMID:1618806</ref>  


===Crystal structure of racemic villin headpiece subdomain crystallized in space group P-1===
==See Also==
 
*[[Villin|Villin]]
 
== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22280019 is the PubMed ID number.
</StructureSection>
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[[Category: Gallus gallus]]
{{ABSTRACT_PUBMED_22280019}}
[[Category: Large Structures]]
 
[[Category: Forest KT]]
==About this Structure==
[[Category: Gellman SH]]
[[3trw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TRW OCA].
[[Category: Mortenson DE]]
 
[[Category: Satyshur KA]]
==Reference==
<ref group="xtra">PMID:022280019</ref><references group="xtra"/>
[[Category: Forest, K T.]]
[[Category: Gellman, S H.]]
[[Category: Mortenson, D E.]]
[[Category: Satyshur, K A.]]
[[Category: D-amino acid]]
[[Category: Quasi-racemate]]
[[Category: Racemate]]
[[Category: Structural protein]]
Retrieved from "https://proteopedia.org/3trw"