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[[Image:2pxh.jpg|left|200px]]<br /><applet load="2pxh" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2pxh, resolution 1.970&Aring;" />
'''Crystal structure of a bipyridylalanyl-tRNA synthetase'''<br />


==About this Structure==
==Crystal structure of a bipyridylalanyl-tRNA synthetase==
2PXH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii] with <scene name='pdbligand=BP5:'>BP5</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] Known structural/functional Site: <scene name='pdbsite=AC1:Bp5+Binding+Site+For+Residue+A+308'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PXH OCA].  
<StructureSection load='2pxh' size='340' side='right'caption='[[2pxh]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2pxh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PXH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BP5:3-(2,2-BIPYRIDIN-5-YL)-L-ALANINE'>BP5</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pxh OCA], [https://pdbe.org/2pxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pxh RCSB], [https://www.ebi.ac.uk/pdbsum/2pxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pxh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SYY_METJA SYY_METJA] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).<ref>PMID:10585437</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/px/2pxh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pxh ConSurf].
<div style="clear:both"></div>


==Reference==
==See Also==
A genetically encoded bidentate, metal-binding amino acid., Xie J, Liu W, Schultz PG, Angew Chem Int Ed Engl. 2007;46(48):9239-42. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17893898 17893898]
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Single protein]]
[[Category: Liu W]]
[[Category: Tyrosine--tRNA ligase]]
[[Category: Schultz PG]]
[[Category: Liu, W.]]
[[Category: Xie J]]
[[Category: Schultz, P.G.]]
[[Category: Xie, J.]]
[[Category: BP5]]
[[Category: bipyridylalanine]]
[[Category: ligase]]
[[Category: metal chelator]]
[[Category: unnatural amino acid]]
 
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Retrieved from "https://proteopedia.org/2pxh"