4d9o: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4d9o is ~~ON HOLD until Paper Publication~~

==Structure of ebolavirus protein VP24 from Reston==

== Structural highlights ==

<table><tr><td colspan='2'>[[4d9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus_-_Reston Reston ebolavirus - Reston]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D9O FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [https://pdbe.org/4d9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [https://www.ebi.ac.uk/pdbsum/4d9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d9o ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/VP24_EBORE VP24_EBORE] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.

~~Authors~~: ~~Zhang, A.P.P.~~

==See Also==

*[[VP24|VP24]]

~~Description~~:

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Reston ebolavirus - Reston]]

[[Category: Zhang APP]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4d9o is ON HOLD  until Paper Publication
+==Structure of ebolavirus protein VP24 from Reston==
+<StructureSection load='4d9o' size='340' side='right'caption='[[4d9o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4d9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus_-_Reston Reston ebolavirus - Reston]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D9O FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [https://pdbe.org/4d9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [https://www.ebi.ac.uk/pdbsum/4d9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d9o ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/VP24_EBORE VP24_EBORE] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
-Authors: Zhang, A.P.P.
+==See Also==
+*[[VP24|VP24]]
-Description:
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Reston ebolavirus - Reston]]
+[[Category: Zhang APP]]