3v8u: Difference between revisions
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< | ==The crystal structure of transferrin binding protein B (TbpB) from Neisseria meningitidis serogroup B== | ||
<StructureSection load='3v8u' size='340' side='right'caption='[[3v8u]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3v8u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_B Neisseria meningitidis serogroup B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V8U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V8U FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v8u OCA], [https://pdbe.org/3v8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v8u RCSB], [https://www.ebi.ac.uk/pdbsum/3v8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v8u ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Neisseria are obligate human pathogens causing bacterial meningitis, septicaemia and gonorrhoea. Neisseria require iron for survival and can extract it directly from human transferrin for transport across the outer membrane. The transport system consists of TbpA, an integral outer membrane protein, and TbpB, a co-receptor attached to the cell surface; both proteins are potentially important vaccine and therapeutic targets. Two key questions driving Neisseria research are how human transferrin is specifically targeted, and how the bacteria liberate iron from transferrin at neutral pH. To address these questions, we solved crystal structures of the TbpA-transferrin complex and of the corresponding co-receptor TbpB. We characterized the TbpB-transferrin complex by small-angle X-ray scattering and the TbpA-TbpB-transferrin complex by electron microscopy. Our studies provide a rational basis for the specificity of TbpA for human transferrin, show how TbpA promotes iron release from transferrin, and elucidate how TbpB facilitates this process. | |||
Structural basis for iron piracy by pathogenic Neisseria.,Noinaj N, Easley NC, Oke M, Mizuno N, Gumbart J, Boura E, Steere AN, Zak O, Aisen P, Tajkhorshid E, Evans RW, Gorringe AR, Mason AB, Steven AC, Buchanan SK Nature. 2012 Feb 12. doi: 10.1038/nature10823. PMID:22327295<ref>PMID:22327295</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3v8u" style="background-color:#fffaf0;"></div> | |||
== | ==See Also== | ||
[[ | *[[Transferrin-binding protein|Transferrin-binding protein]] | ||
[[Category: Neisseria meningitidis serogroup | == References == | ||
[[Category: Buchanan | <references/> | ||
[[Category: Easley | __TOC__ | ||
[[Category: Noinaj | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Neisseria meningitidis serogroup B]] | |||
[[Category: Buchanan SK]] | |||
[[Category: Easley N]] | |||
[[Category: Noinaj N]] | |||
Latest revision as of 02:33, 21 November 2024
The crystal structure of transferrin binding protein B (TbpB) from Neisseria meningitidis serogroup B
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